Document Detail

Anticancer peptide SVS-1: efficacy precedes membrane neutralization.
MedLine Citation:
PMID:  22839778     Owner:  NLM     Status:  MEDLINE    
Anticancer peptides are polycationic amphiphiles capable of preferentially killing a wide spectrum of cancer cells relative to noncancerous cells. Their primary mode of action is an interaction with the cell membrane and subsequent activation of lytic effects; however, the exact mechanism responsible for this mode of action remains controversial. Using zeta potential analyses we demonstrate the interaction of a small anticancer peptide with membrane model systems and cancer cells. Electrostatic interactions have a pivotal role in the cell killing process, and in contrast to the antimicrobial peptides action cell death occurs without achieving full neutralization of the membrane charge.
Diana Gaspar; Ana Salomé Veiga; Chomdao Sinthuvanich; Joel P Schneider; Miguel A R B Castanho
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't     Date:  2012-08-03
Journal Detail:
Title:  Biochemistry     Volume:  51     ISSN:  1520-4995     ISO Abbreviation:  Biochemistry     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-09-20     Completed Date:  2012-10-29     Revised Date:  2013-08-15    
Medline Journal Info:
Nlm Unique ID:  0370623     Medline TA:  Biochemistry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6263-5     Citation Subset:  IM    
Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisbon, Portugal.
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MeSH Terms
Antineoplastic Agents / chemistry,  pharmacology*
Cell Death / drug effects
Cell Line, Tumor
Inhibitory Concentration 50
Membranes, Artificial
Peptides / chemistry,  pharmacology*
Phosphatidylcholines / chemistry
Phosphatidylserines / chemistry
Static Electricity
Grant Support
Reg. No./Substance:
0/Antineoplastic Agents; 0/Membranes, Artificial; 0/Peptides; 0/Phosphatidylcholines; 0/Phosphatidylserines; 0/SVS-1 peptide; 40290-44-6/1-palmitoyl-2-oleoylglycero-3-phosphoserine; TE895536Y5/1-palmitoyl-2-oleoylphosphatidylcholine

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