Document Detail

Anticancer mechanisms of action of two small amphipathic β(2,2)-amino acid derivatives derived from antimicrobial peptides.
MedLine Citation:
PMID:  22820149     Owner:  NLM     Status:  Publisher    
We have recently discovered that small antimicrobial β(2,2)-amino acid derivatives (Mw<500) also display activity against cancer cells. To explore their drug potential, we have presently investigated the mechanisms of action of two derivatives BAA-1 (IC(50) 8.1μg/ml) and BAA-2 (IC(50) 3.8μg/ml) on Ramos human Burkitt's lymphoma cells. Studies using annexin-V-FITC/PI staining and flow cytometry revealed essential mechanistic differences, which was confirmed by screening for active caspases, investigation of mitochondrial membrane potential, and electron microscopy studies. Our results indicated that BAA-1 killed Ramos cells by destabilizing the cell membrane, whereas BAA-2 caused apoptosis by the mitochondrial-mediated pathway.
Dominik Ausbacher; Gunbjørg Svineng; Terkel Hansen; Morten B Strøm
Related Documents :
11923439 - Functional asymmetries in on and off ganglion cells of primate retina.
15338009 - The contribution of spike threshold to the dichotomy of cortical simple and complex cells.
6265979 - Effects of opioid peptides on synaptic potentials in explants of rat hippocampus.
21929029 - Dynamics and morphology characteristics of cell colonies with radially spreading growth...
22183159 - A microchamber array for single cell isolation and analysis of intracellular biomolecules.
16977629 - Mitral cells in the olfactory bulb of adult zebrafish (danio rerio): morphology and dis...
11923439 - Functional asymmetries in on and off ganglion cells of primate retina.
4084329 - Seronegative polyarthritis in giant cell arteritis.
24638869 - Magnetic manipulation of bacterial magnetic nanoparticle-loaded neurospheres.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-18
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  -     ISSN:  0006-3002     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Department of Pharmacy, Faculty of Health Sciences, University of Tromsø, 9037 Tromsø, Norway.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Structure of solid-supported lipid membrane probed by noble metal nanoparticle deposition.
Next Document:  Alpha-synuclein pore forming activity upon membrane association.