Document Detail


Anticancer efficacy of a novel propofol-linoleic acid-loaded escheriosomal formulation against murine hepatocellular carcinoma.
MedLine Citation:
PMID:  23311988     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Aim: The preparation and characterization of a novel escheriosomal nanoparticle formulation of a potent anticancer conjugate, 2,6-diisopropylphenol-linoleic acid (2,6P-LA), and evaluation of its anticancer efficacy against diethyl nitrosamine-induced hepatocellular carcinoma (HCC) in BALB/c mice. Materials & methods: Escheriosomized 2,6P-LA nanoparticles were characterized for size, zeta potential, entrapment efficiency, release kinetics and in vivo toxicity. Their anticancer potential was evaluated on the basis of survival, DNA fragmentation, caspase-3 activation, western blot analysis of apoptotic factors and histopathological changes in hepatocytes of treated animals. Results: The escheriosomized 2,6P-LA nanoparticles exhibited low toxicity, biocompatibility and bioavailability. As revealed by apoptosis induction, survival rate, expression profiles of Bax, Bcl-2 and caspase-9, escheriosomized 2,6P-LA nanoparticles were more effective in the treatment of HCC than the free form of 2,6P-LA in experimental animals. Conclusion: 2,6P-LA-bearing escheriosome nanoparticles are effective in suppressing HCC in mice. Original submitted 17 January 2012; Revised submitted 27 August 2012.
Authors:
Azmat Ali Khan; Mumtaz Jabeen; Aijaz Ahmed Khan; Mohammad Owais
Related Documents :
10818238 - Switch of histamine receptor expression from h2 to h1 during differentiation of monocyt...
17684038 - Human immature monocyte-derived dendritic cells produce and secrete alpha-defensins 1-3.
2548738 - A flow cytometric and immunofluorescence microscopic study of tumor necrosis factor pro...
19060758 - Propranolol restores the tumor necrosis factor-alpha response of circulating inflammato...
21480758 - Suppression of inflammatory responses after onset of collagen-induced arthritis in mice...
24026668 - Early down regulation of the glial kir4.1 and glt-1 expression in pericontusional corte...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-14
Journal Detail:
Title:  Nanomedicine (London, England)     Volume:  -     ISSN:  1748-6963     ISO Abbreviation:  Nanomedicine (Lond)     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101278111     Medline TA:  Nanomedicine (Lond)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh-202002, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Osteogenic efficacy enhancement of kaempferol through an engineered layer-by-layer matrix: a study i...
Next Document:  Pharmacoeconomic assessment of therapy for invasive aspergillosis.