Document Detail


Anticancer activity of Hemsleya amabilis extract.
MedLine Citation:
PMID:  12204774     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hemsleya amabilis extract is derived from the medicinal herb Hemsleya amabilis, which has long been used to treat cancer and many other conditions. The underlying mechanism is not clear. To investigate Hemsleya amabili's anticancer activity, we have treated different types of cancer cells including human astrocytoma U87 cells, breast cancer cells MDA-MB-231and Jurkat cells with Hemsleya amabilis extract. This agent significantly inhibited tumor cell growth and colony formation at various concentrations. When astrocytoma cells were seeded in the presence of Hemsleya amabilis extract at very low concentrations, cell spreading was greatly inhibited. Hemsleya amabilis extract also promoted tumor cell death in all the tested cell lines, but with varied sensitivities. Apoptotic assays with Annexin V staining demonstrated that Hemsleya amabilis extract induced astrocytoma cell apoptosis at different concentrations.
Authors:
Jin Wu; Yaojiong Wu; Burton B Yang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Life sciences     Volume:  71     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-09-02     Completed Date:  2002-10-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  2161-70     Citation Subset:  IM    
Affiliation:
Room 108, South Wing, Patrick Manson Building, The University of Hong Kong, 7 Sassoon Road, Pokfulam, Hong Kong, China. wujin@hkucc.hku.hk
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents, Phytogenic / pharmacology*
Apoptosis / drug effects
Cell Count
Cell Survival / drug effects
Drug Screening Assays, Antitumor
Humans
Plant Extracts / pharmacology*
Plants, Medicinal / chemistry*
Spectrometry, Fluorescence
Tumor Cells, Cultured
Tumor Stem Cell Assay
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Plant Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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