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Anticancer Effects of Eleven Triterpenoids Derived from Antrodia camphorata.
MedLine Citation:
PMID:  22753732     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Eleven derivatives from Antrodia camphorata were isolated in order to evaluate their selective cytotoxicity toward 14 types of human cancer cell and two non-transformed cell types. Among these triterpenoids, methyl antcinate A (MAA) exhibited the most potent spectrum of anticancer effects in KB cells, four different oral cancer cell lines (TSCCa, GNM, OC-2, and OEC-M1), Panc-1, BT474, PC-3, OVCAR-3, HeLa, and U2OS cells with high selectivity indices (CC(50)/IC(50)). The expression of B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax), and poly(ADP-ribose) polymerase (PARP) of PC-3 cells tested by western blotting suggested that MAA exerts cell death through the caspase-dependent cascade and the Bax-mediated mitochondrial apoptotic pathway, not only on liver and oral cancer cells but on other types as well, including prostate cancer, in a dose-dependent manner. In addition to MAA, methyl antcinate B, dehydroeburicoic acid, and 15α-acetyl-dehydrosulfurenic acid also exhibited significant selective cytotoxic effects to respective cancer cells. Modifications of these triterpenoids may lead to the development of more potent anticancer drugs.
Authors:
Yi-Pang Lee; Wan-Chi Tsai; Chih-Jan Ko; Yerra Koteswara Rao; Chiung-Ru Yang; Dar-Ren Chen; Ming-Hui Yang; Chi-Chiang Yang; Yew-Min Tzeng
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  32     ISSN:  1791-7530     ISO Abbreviation:  Anticancer Res.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  2727-34     Citation Subset:  IM    
Affiliation:
Chung Shan Medical University, 110, Section 1, Chien-Kuo North Road, Taichung, Taiwan 40201, R.O.C. Tel: +886 424730022/12415, cyang@csmu.edu.tw.
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