| Anticancer Drug Discovery from the Marine Environment. | |
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MedLine Citation:
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PMID: 22216781 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Discovery, isolation, biochemical/pharmacological characterization, pre-clinical and clinical trials of drugs derived from the marine environment are continuously developing and increasing. One of the most promising area is cancer therapy. Currently, there are two drugs approved by the Food and Drug Administration (FDA) and European Agency for the Evaluation of Medicinal Products (EMA) in cancer treatment, namely Cytarabine (Cytosar-U1®) and Eribulin (E7389 or Halaven®). Trabectedin (ET-743 or Yondelis1®), approved by EMA, is completing key Phase III studies in the U.S. for final approval. It was estimated that 118 marine natural products (MNPs) are currently in preclinical trials, 22 MNPs in clinical trials and 3 MNPs on the market. The characteristics and selectivity profiles of new drugs for cancer therapy, as well as drugs disclosed in related patent applications, will be the focus of this review, providing a brief and ready to use reference. |
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Authors:
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Candida Nastrucci; Patrizia Russo |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-01 |
Journal Detail:
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Title: Recent patents on anti-cancer drug discovery Volume: - ISSN: 2212-3970 ISO Abbreviation: Recent Pat Anticancer Drug Discov Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-1-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101266081 Medline TA: Recent Pat Anticancer Drug Discov Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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IRCCS "San Raffaele Pisana", Via di Val Cannuta 247-249, 00166 Rome, Italy. patrizia_russo@hotmail.it. |
Export Citation:
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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