Document Detail


Antibradykinin active material in Aloe saponaria.
MedLine Citation:
PMID:  7143219     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A material having antibradykinin activity on isolated guinea pig ileum was partially purified from the nondialysate of the pulp of Aloe saponaria by repetition of gel chromatography using a hydrophilic polyvinyl gel and dextran gels. From the results of amino acid and carbohydrate analyses, the antibradykinin-active material was estimated to be a glycoprotein. It was found that this material catalyzes the hydrolysis of bradykinin at pH 7.4. The results of peptide analysis using reversed-phase high-performance liquid chromatography coupled with amino acid analysis indicate that this glycoprotein cleaves the Gly4-Phe5 and Pro7-Phe8 bonds of the bradykinin molecule.
Authors:
A Yagi; N Harada; H Yamada; S Iwadare; I Nishioka
Related Documents :
7109979 - Purification and characterization of spirosomes in lactobacillus brevis.
7340829 - Identification of fatty acid synthetase messenger rna on free polyribosomes isolated fr...
3093389 - Purification and physicochemical characterization of schistosoma mansoni egg allergen r...
7438059 - Purification and partial characterization of a preneoplastic antigen in liver carcinoge...
1281089 - Native horizontal ultrathin polyacrylamide gel electrophoresis of proteins under basic ...
1917839 - Biosynthesis of vitamin b12: stepwise amidation of carboxyl groups b, d, e, and g of co...
24263489 - A safe method to acid digest small samples of biological tissues for graphite furnace a...
818369 - The effect of temperature on the fatty acid composition of tetrahymena pyriformis wh-14.
24788579 - Recognition of free tryptophan in water by synthetic pseudopeptides: fluorescence and t...
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  71     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1983-01-19     Completed Date:  1983-01-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1172-4     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aloe / analysis*
Amino Acids / analysis
Animals
Bradykinin / antagonists & inhibitors*
Chemical Phenomena
Chemistry
Guinea Pigs
Ileum / drug effects
Muscle Contraction / drug effects
Muscle, Smooth / drug effects
Plants, Medicinal / analysis*
Chemical
Reg. No./Substance:
0/Amino Acids; 58-82-2/Bradykinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Bioavailability of griseofulvin from tablets in beagle dogs and correlation with dissolution rate an...
Next Document:  Lipid-soluble inhibitors of dihydrofolate reductase. III: Quantitative thin-layer and high-performan...