Document Detail

Antibradykinin active material in Aloe saponaria.
MedLine Citation:
PMID:  7143219     Owner:  NLM     Status:  MEDLINE    
A material having antibradykinin activity on isolated guinea pig ileum was partially purified from the nondialysate of the pulp of Aloe saponaria by repetition of gel chromatography using a hydrophilic polyvinyl gel and dextran gels. From the results of amino acid and carbohydrate analyses, the antibradykinin-active material was estimated to be a glycoprotein. It was found that this material catalyzes the hydrolysis of bradykinin at pH 7.4. The results of peptide analysis using reversed-phase high-performance liquid chromatography coupled with amino acid analysis indicate that this glycoprotein cleaves the Gly4-Phe5 and Pro7-Phe8 bonds of the bradykinin molecule.
A Yagi; N Harada; H Yamada; S Iwadare; I Nishioka
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  71     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1983-01-19     Completed Date:  1983-01-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1172-4     Citation Subset:  IM    
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MeSH Terms
Aloe / analysis*
Amino Acids / analysis
Bradykinin / antagonists & inhibitors*
Chemical Phenomena
Guinea Pigs
Ileum / drug effects
Muscle Contraction / drug effects
Muscle, Smooth / drug effects
Plants, Medicinal / analysis*
Reg. No./Substance:
0/Amino Acids; 58-82-2/Bradykinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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