Document Detail

Antibody to intermediate filaments of the cytoskeleton in patients with Behçet's disease.
MedLine Citation:
PMID:  3780056     Owner:  NLM     Status:  MEDLINE    
Antibodies to 10-nm intermediate filaments (anti-IF) were determined in the sera of 30 patients with Behçet's disease (BD), in addition to C-reactive protein and C9, and an attempt has been made to determine whether the presence of anti-IF indicate disease activity. The vimentin type of anti-IF was found to be positive in 14 out of 30 patients with BD (47%), whereas it was positive in 35% of the patients with rheumatoid arthritis (20 cases), 16% of the patients with systemic lupus erythematosus (19 cases) and in only 9% of the normal controls. The anti-IF were predominantly IgG class and the titers in BD were significantly higher than those in normal controls. Out of the 14 patients with anti-IF, 10 showed significantly increased levels of serum C9 and 8 showed increased levels of CRP activity. Only one patient showed increased C9, but was negative for anti-IF and CRP. The presence of anti-IF in the patients' sera was found to be a more sensitive indicator, though not specific, for the clinical assessment of disease activity.
T Akoğlu; H Kozakoğlu; E Akoğlu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical immunology and immunopathology     Volume:  41     ISSN:  0090-1229     ISO Abbreviation:  Clin. Immunol. Immunopathol.     Publication Date:  1986 Dec 
Date Detail:
Created Date:  1987-01-13     Completed Date:  1987-01-13     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0356637     Medline TA:  Clin Immunol Immunopathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  427-32     Citation Subset:  IM    
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MeSH Terms
Antibody Specificity
Arthritis, Rheumatoid / immunology
Autoantibodies / immunology*
Behcet Syndrome / immunology*
C-Reactive Protein / metabolism
Complement C9 / metabolism
Cytoskeleton / immunology*
Intermediate Filaments / immunology*
Lupus Erythematosus, Systemic / immunology
Vimentin / immunology
Reg. No./Substance:
0/Autoantibodies; 0/Complement C9; 0/Vimentin; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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