Document Detail

Antibody to hepatitis-B core antigen in patients with primary hepatic carcinoma.
MedLine Citation:
PMID:  49648     Owner:  NLM     Status:  MEDLINE    
Antibody to hepatitis-B core antigen (anti-HBc) was assayed in the serum of patients with primary hepatic carcinoma (P.H.C.) and controls from Hong Kong, West Africa, and the United States. In each region the prevalence of anti-HBc was higher in P.H.C. patients than in controls, ranging from 70 to 95% in the patients and from 20 to 68% in the controls from Asia and Africa; 24% of P.H.C. patients and 4% of controls from the U.S. had anti-HBc. These data support the hypothesis that chronic infection with hepatitis-B virus is aetiologically related to P.H.C., especially in Asia and Africa, although other factors must also be involved.
P Maupas; B Werner; B Larouzé; I Millman; W T London; A O'Connell; B S Blumberg
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Lancet     Volume:  2     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1975 Jul 
Date Detail:
Created Date:  1975-10-10     Completed Date:  1975-10-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  9-11     Citation Subset:  AIM; IM    
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MeSH Terms
Antibodies, Viral*
Antigens, Viral
Carrier State*
Culture Techniques
Hepatitis B / complications,  immunology
Hepatitis B Antigens / isolation & purification
Hepatitis B virus / immunology*
Hong Kong
Liver / immunology
Liver Extracts
Liver Neoplasms / etiology*
United States
Reg. No./Substance:
0/Antibodies, Viral; 0/Antigens, Viral; 0/Hepatitis B Antigens; 0/Liver Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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