| Antibody response to glycoprotein E after bovine herpesvirus type 1 infection in passively immunised, glycoprotein E-negative calves. | |
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MedLine Citation:
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PMID: 10097325 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was conducted to determine whether young calves with maternal antibodies against bovine herpesvirus type 1 (BHV-1) but without antibodies against glycoprotein E (gE) can produce an active antibody response to gE after a BHV-1 infection. Five calves received at birth colostrum from gE-seronegative cows which had been vaccinated two or three times with an inactivated BHV-1, gE-deleted marker vaccine. After inoculation with a wild-type virulent strain of BHV-1, all the passively immunised gE-negative calves shed virus in large amounts in their nasal secretions. All the calves seroconverted to gE within two to four weeks after inoculation and then had high levels of gE antibodies for at least four months. The development of an active cell-mediated immune response was also detected by in vitro BHV-1-specific interferon-gamma assays. All the calves were latently infected, because one of them re-excreted the virus spontaneously and the other four did so after being treated with dexamethasone. The results showed that under the conditions of this work the gE-negative marker could also distinguish between passively immunised and latently infected calves. |
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Authors:
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M Lemaire; F Schynts; G Meyer; E Thiry |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Veterinary record Volume: 144 ISSN: 0042-4900 ISO Abbreviation: Vet. Rec. Publication Date: 1999 Feb |
Date Detail:
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Created Date: 1999-05-27 Completed Date: 1999-05-27 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0031164 Medline TA: Vet Rec Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 172-6 Citation Subset: IM |
Affiliation:
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Virology Department, Faculty of Veterinary Medicine, University of Liège, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Viral / blood* Cattle Cattle Diseases / immunology* Colostrum / immunology* DNA, Viral / isolation & purification Female Glycoproteins / immunology Herpesviridae Infections / immunology, veterinary* Herpesvirus 1, Bovine / immunology*, isolation & purification Immunity, Maternally-Acquired* Interferon-gamma / blood Pregnancy Vaccines, Inactivated |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Viral; 0/DNA, Viral; 0/Glycoproteins; 0/Vaccines, Inactivated; 82115-62-6/Interferon-gamma |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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