Document Detail

Antibody response after single-visit full-mouth ultrasonic debridement versus quadrant-wise therapy.
MedLine Citation:
PMID:  16856899     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: The aim of this study was to compare serum antibody responses to periodontal pathogens after single-visit full-mouth ultrasonic debridement and quadrant-wise therapy. MATERIAL AND METHODS: Thirty-six subjects with chronic periodontitis were randomized into three groups: quadrant-wise debridement in four visits, one-visit full-mouth debridement with water and with povidone iodine. Blood samples were collected before and immediately after treatment and 1, 3 and 6 months post-therapy. Serum antibody titres and avidity to Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, Prevotella intermedia and Treponema denticola were determined by enzyme-linked immunosorbent assay (ELISA) and thiocyanate ELISA, respectively. RESULTS: IgG titres to P. gingivalis significantly decreased at 1, 3 and 6 months in full-mouth debridement with water group, while significant reductions were seen only at 3 and 6 months after quadrant-wise debridement. Both full-mouth groups showed significant reduction in IgG titres to A. actinomycetemcomitans at 3 and 6 months. Significant increases in antibody avidity to P. gingivalis and A. actinomycetemcomitans were noted 3 months following full-mouth debridement with povidone. CONCLUSION: Both full-mouth and quadrant treatments generally resulted in a decrease in antibody titres and increase in antibody avidity. Full-mouth debridement induced an earlier reduction of IgG titre to P. gingivalis and A. actinomycetemcomitans, than quadrant-wise therapy.
Dongqing Wang; Geena Koshy; Toshiyuki Nagasawa; Yoko Kawashima; Makoto Kiji; Hiroshi Nitta; Shigeru Oda; Isao Ishikawa
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2006-07-20
Journal Detail:
Title:  Journal of clinical periodontology     Volume:  33     ISSN:  0303-6979     ISO Abbreviation:  J. Clin. Periodontol.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-21     Completed Date:  2006-10-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0425123     Medline TA:  J Clin Periodontol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  632-8     Citation Subset:  D; IM    
Periodontology, Department of Hard Tissue Engineering,Tokyo Medical and Dental University, Tokyo, Japan.
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MeSH Terms
Actinobacillus actinomycetemcomitans / immunology
Anti-Infective Agents, Local / therapeutic use
Antibodies, Bacterial / blood,  immunology*
Antibody Affinity / immunology
Chronic Disease
Dental Plaque / microbiology
Follow-Up Studies
Immunoglobulin G / blood,  immunology
Periodontitis / immunology,  microbiology,  therapy
Porphyromonas gingivalis / immunology
Povidone-Iodine / therapeutic use
Prevotella intermedia / immunology
Saliva / microbiology
Single-Blind Method
Subgingival Curettage / methods*
Treponema denticola / immunology
Ultrasonic Therapy*
Reg. No./Substance:
0/Anti-Infective Agents, Local; 0/Antibodies, Bacterial; 0/Immunoglobulin G; 25655-41-8/Povidone-Iodine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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