Document Detail

Antibody repertoire development in fetal and neonatal piglets. XVI. Influenza stimulates adaptive immunity, class switch and diversification of the IgG repertoire encoded by downstream Cγ genes.
MedLine Citation:
PMID:  23320646     Owner:  NLM     Status:  MEDLINE    
Infection of germ-free isolator piglets with swine influenza (S-FLU) that generates dsRNA during replication causes elevation of immunoglobulins in serum and bronchoalveolar lavage, a very weak response to trinitrophenyl conjugates but an immune response to S-FLU. The increased immunoglobulin levels result mainly from the polyclonal activation of B cells during the infection, but model antigen exposure may contribute. The 10-fold increase in local and serum IgG accompanies a 10-fold decrease in the transcription of IgG3 in the tracheal-bronchial lymph nodes and in the ileal Peyer's patches. Infection results in class switch recombination to downstream Cγ genes, which diversify their repertoire; both features are diagnostic of adaptive immunity. Meanwhile the repertoires of IgM and IgG3 remain undiversified suggesting that they encode innate, natural antibodies. Whereas IgG3 may play an initial protective role, antibodies encoded by downstream Cγ genes with diversified repertoires are predicted to be most important in long-term protection against S-FLU.
John E Butler; XiuZhu Sun; Nancy Wertz; Amy L Vincent; Eraldo L Zanella; Kelly M Lager
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Immunology     Volume:  138     ISSN:  1365-2567     ISO Abbreviation:  Immunology     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-16     Completed Date:  2013-03-11     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  0374672     Medline TA:  Immunology     Country:  England    
Other Details:
Languages:  eng     Pagination:  134-44     Citation Subset:  IM    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
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MeSH Terms
Adaptive Immunity*
Animals, Newborn
Antibodies, Viral / blood,  genetics,  immunology*
Cell Line
Immunoglobulin Class Switching / genetics,  immunology
Immunoglobulin G / blood,  genetics,  immunology*
Immunoglobulin M / genetics,  immunology
Influenza A Virus, H1N1 Subtype / immunology*
Orthomyxoviridae Infections / blood,  genetics,  immunology*
Peyer's Patches / immunology
Somatic Hypermutation, Immunoglobulin / genetics,  immunology
Swine Diseases / blood,  genetics,  immunology*
Reg. No./Substance:
0/Antibodies, Viral; 0/Immunoglobulin G; 0/Immunoglobulin M

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