| Antibody repertoire development in fetal and neonatal piglets. XVI. Influenza stimulates adaptive immunity, class switch and diversification of the IgG repertoire encoded by downstream Cγ genes. | |
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MedLine Citation:
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PMID: 23320646 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Infection of germ-free isolator piglets with swine influenza (S-FLU) that generates dsRNA during replication causes elevation of immunoglobulins in serum and bronchoalveolar lavage, a very weak response to trinitrophenyl conjugates but an immune response to S-FLU. The increased immunoglobulin levels result mainly from the polyclonal activation of B cells during the infection, but model antigen exposure may contribute. The 10-fold increase in local and serum IgG accompanies a 10-fold decrease in the transcription of IgG3 in the tracheal-bronchial lymph nodes and in the ileal Peyer's patches. Infection results in class switch recombination to downstream Cγ genes, which diversify their repertoire; both features are diagnostic of adaptive immunity. Meanwhile the repertoires of IgM and IgG3 remain undiversified suggesting that they encode innate, natural antibodies. Whereas IgG3 may play an initial protective role, antibodies encoded by downstream Cγ genes with diversified repertoires are predicted to be most important in long-term protection against S-FLU. |
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Authors:
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John E Butler; XiuZhu Sun; Nancy Wertz; Amy L Vincent; Eraldo L Zanella; Kelly M Lager |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Immunology Volume: 138 ISSN: 1365-2567 ISO Abbreviation: Immunology Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-01-16 Completed Date: 2013-03-11 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0374672 Medline TA: Immunology Country: England |
Other Details:
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Languages: eng Pagination: 134-44 Citation Subset: IM |
Copyright Information:
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© 2012 Blackwell Publishing Ltd. |
Affiliation:
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Department of Microbiology, Carver College of Medicine, Iowa City, IA 52240, USA. johnbutler@uiowa.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptive Immunity* Animals Animals, Newborn Antibodies, Viral / blood, genetics, immunology* Cell Line Dogs Fetus Immunoglobulin Class Switching / genetics, immunology Immunoglobulin G / blood, genetics, immunology* Immunoglobulin M / genetics, immunology Influenza A Virus, H1N1 Subtype / immunology* Orthomyxoviridae Infections / blood, genetics, immunology* Peyer's Patches / immunology Somatic Hypermutation, Immunoglobulin / genetics, immunology Swine Swine Diseases / blood, genetics, immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Viral; 0/Immunoglobulin G; 0/Immunoglobulin M |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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