Document Detail


Antibody-mimicking polymers as chiral stationary phases in HPLC.
MedLine Citation:
PMID:  8686916     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Antibody-mimicking synthetic polymers, selective for various optically active amino acid derivatives and peptides, were prepared by noncovalent molecular imprinting. A novel approach, in which the branched, trifunctional cross-linkers pentaerythritol triacrylate and 2,2-bis(hydroxymethyl)butanol trimethacrylate were copolymerized with methacrylic acid, is described. The polymers were subsequently applied as chiral stationary phases in high-performance liquid chromatography. They were superior to previously reported noncovalent molecularly imprinted polymers used for chiral separations in that they showed considerably higher load capacity, increased selectivity, and better resolving capability.
Authors:
M Kempe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Analytical chemistry     Volume:  68     ISSN:  0003-2700     ISO Abbreviation:  Anal. Chem.     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-08-21     Completed Date:  1996-08-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370536     Medline TA:  Anal Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1948-53     Citation Subset:  IM    
Affiliation:
Department of Pure and Applied Biochemistry, University of Lund, Sweden. Maria.Kempe@tbiokem.lth.se or Kempe@chemsun.chem.umn.edu
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Antibodies / chemistry*
Chromatography, High Pressure Liquid
Molecular Sequence Data
Polymers / chemistry*
Chemical
Reg. No./Substance:
0/Antibodies; 0/Polymers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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