Document Detail

Antibody differentiation: apparent sequence identity between variable regions shared by IgA and IgG immunoglobulins.
MedLine Citation:
PMID:  1062807     Owner:  NLM     Status:  MEDLINE    
We have analyzed a pair of human myeloma immunoglobulins (biclonal proteins) of the IgG and IgA classes from a single patient, GR. The light chains are identical in amino-acid sequence over 40 residues at their NH2-terminus, hwereas the heavy chains are identical throughout 45 residues of their NH2-terminus. Additional chemical and serological studies suggest the light chains and variable regions of the heavy chains (VH) are very similar, if not identical. The implications of these and of other published studies are discussed with regard to (i) the association of one VH region with multiple constant regions of the heavy chain (CH regions), (ii) two alternative types of V-C joining mechanisms, (iii) the differentiation of antibody-producing cells, and (iv) three categories of biclonal immunoglobulins.
C Sledge; D S Fair; B Black; R G Krueger; L Hood
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  73     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1976 Mar 
Date Detail:
Created Date:  1976-06-02     Completed Date:  1976-06-02     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  923-7     Citation Subset:  IM    
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MeSH Terms
Amino Acid Sequence
Antibody Formation*
Antibody-Producing Cells / cytology,  immunology
Cell Differentiation
Immunoglobulin A / analysis,  biosynthesis*
Immunoglobulin G / analysis,  biosynthesis*
Models, Biological
Myeloma Proteins / analysis,  biosynthesis*
Reg. No./Substance:
0/Immunoglobulin A; 0/Immunoglobulin G; 0/Myeloma Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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