Document Detail


Antibody-dependent cell-mediated virus inhibition antibody activity does not correlate with risk of HIV-1 superinfection.
MedLine Citation:
PMID:  23344546     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previous studies of HIV-infected women with high-risk behavior have indicated that neither neutralizing antibody nor cellular immunity elicited by an initial HIV-1 infection is associated with protection against superinfection with a different HIV-1 strain. Here, we measured antibody-dependent cell-mediated virus inhibition (ADCVI) antibody activity in the plasma of 12 superinfected cases and 36 singly infected matched controls against 2 heterologous viruses. We found no association between plasma ADCVI activity and superinfection status. ADCVI antibody activity against heterologous virus elicited by the original infection may not contribute to preventing a superinfecting HIV-1.
Authors:
Donald N Forthal; Gary Landucci; Bhavna Chohan; Barbra A Richardson; R Scott McClelland; Walter Jaoko; Catherine Blish; Julie Overbaugh
Related Documents :
187776 - Evaluation of moloney murine sarcoma and leukemia virus complex as a model for airborne...
3477906 - Characterization of cell lines derived from enlarged spleens induced in c57bl/6 mice by...
6251276 - Frequent isolation of ecotropic murine leukemia virus after x-ray irradiation of c57bl/...
23041316 - Reactivation of latent hiv-1 by inhibition of brd4.
6288856 - The isolation and characterization of mutants of herpes simplex virus type 1 that induc...
11181386 - High-dose intravenous ribavirin therapy for subacute sclerosing panencephalitis.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of acquired immune deficiency syndromes (1999)     Volume:  63     ISSN:  1944-7884     ISO Abbreviation:  J. Acquir. Immune Defic. Syndr.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-11     Completed Date:  2013-06-24     Revised Date:  2014-05-07    
Medline Journal Info:
Nlm Unique ID:  100892005     Medline TA:  J Acquir Immune Defic Syndr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  31-3     Citation Subset:  IM; X    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Antibodies, Neutralizing / blood,  immunology
Antibody-Dependent Cell Cytotoxicity / immunology*
Case-Control Studies
Female
HIV Antibodies / blood,  immunology*
HIV Infections / immunology*,  virology
HIV-1 / classification,  genetics,  immunology*,  pathogenicity
Humans
Kenya
Superinfection / immunology*,  prevention & control,  virology
Grant Support
ID/Acronym/Agency:
R37 AI038518/AI/NIAID NIH HHS; R37-AI038518/AI/NIAID NIH HHS; UL1 TR000153/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Neutralizing; 0/HIV Antibodies
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  High Viral Load and Elevated Angiogenic Markers Associated with Increased Risk of Preeclampsia among...
Next Document:  CD4 count slope and mortality in HIV-infected patients on antiretroviral therapy: multicohort analys...