| Antibodies, viruses and vaccines. | |
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MedLine Citation:
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PMID: 12209139 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neutralizing antibodies are crucial for vaccine-mediated protection against viral diseases. They probably act, in most cases, by blunting the infection, which is then resolved by cellular immunity. The protective effects of neutralizing antibodies can be achieved not only by neutralization of free virus particles, but also by several activities directed against infected cells. In certain instances, non-neutralizing antibodies contribute to protection. Several viruses, such as HIV, have evolved mechanisms to evade neutralizing-antibody responses, and these viruses present special challenges for vaccine design that are now being tackled. |
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Authors:
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Dennis R Burton |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Nature reviews. Immunology Volume: 2 ISSN: 1474-1733 ISO Abbreviation: Nat. Rev. Immunol. Publication Date: 2002 Sep |
Date Detail:
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Created Date: 2002-09-04 Completed Date: 2002-10-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101124169 Medline TA: Nat Rev Immunol Country: England |
Other Details:
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Languages: eng Pagination: 706-13 Citation Subset: IM |
Affiliation:
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Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. burton@scripps.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Viral / biosynthesis, immunology* Antiviral Agents / immunology Drug Design HIV Infections / immunology, prevention & control HIV-1 / immunology Humans Immunity, Cellular Immunologic Memory Vaccination Viral Vaccines / administration & dosage, immunology* Virus Diseases / immunology, prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Viral; 0/Antiviral Agents; 0/Viral Vaccines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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