Document Detail


Antibodies to xanthine oxidase: elevated levels in patients with acute myocardial infarction.
MedLine Citation:
PMID:  2102807     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Circulating antibodies to whole dried cows' milk, previously reported to be elevated in patients with myocardial infarction, have been shown to be directed mainly to the bovine milk fat globule membrane. Human antibodies against the bovine milk fat globule membrane themselves interact primarily with the enzyme, xanthine oxidase. Comparison of anti-(xanthine oxidase) antibody levels in 107 patients, who had suffered a myocardial infarction, with those in 86 control subjects showed significantly higher IgM levels in the patients with myocardial infarction. No corresponding differences were found for IgG or IgA anti-(xanthine oxidase) antibodies. Total levels of IgM class immunoglobulins did not differ between patients and controls. Serial assays following myocardial infarction showed no evidence that raised levels of IgM anti-(xanthine oxidase) antibodies result from the infarction itself.
Authors:
R Harrison; M Benboubetra; S Bryson; R D Thomas; P C Elwood
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cardioscience     Volume:  1     ISSN:  1015-5007     ISO Abbreviation:  Cardioscience     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1991-10-03     Completed Date:  1991-10-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9014943     Medline TA:  Cardioscience     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  183-9     Citation Subset:  IM    
Affiliation:
Biochemistry Department, University of Bath.
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MeSH Terms
Descriptor/Qualifier:
Antibodies / analysis*
Antigens / immunology
Electrophoresis, Polyacrylamide Gel
Enzyme-Linked Immunosorbent Assay
Humans
Immunoblotting
Immunoglobulin M / analysis
Male
Membrane Glycoproteins / immunology
Middle Aged
Mucin-1
Myocardial Infarction / immunology*
Xanthine Oxidase / immunology*
Chemical
Reg. No./Substance:
0/Antibodies; 0/Antigens; 0/Immunoglobulin M; 0/Membrane Glycoproteins; 0/Mucin-1; EC 1.17.3.2/Xanthine Oxidase

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