Document Detail

Antibodies to toluene diisocyanate in patients with and without dialysis anaphylaxis.
MedLine Citation:
PMID:  1847799     Owner:  NLM     Status:  MEDLINE    
In a majority of patients with anaphylaxis to dialysis, ethylene oxide has been identified as an etiologic agent. In a significant minority of patients sustaining such reactions, the antigen remains unidentified. Conflicting results have been published with regard to isocyanates as a possible antigen. The authors studied 19 hemodialysis patients with anaphylaxis in whom IgE against ethylene oxide-human serum albumin (ETO-HSA) was not identified (Group 1) and 25 peritoneal dialysis patients without anaphylaxis (Group 2). IgE against toluene diisocyanate-human serum albumin (TDI-HSA) was found in one patient in Group 1, and a similar incidence of IgG against TDI-HSA in Group 1 (16%) and Group 2 (12%) was noted. The results do not suggest that IgE against TDI-HSA is an important cause of dialysis anaphylaxis.
L C Grammer; K E Harris; M A Shaughnessy; J Dolovich; R Patterson; S Evans
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Artificial organs     Volume:  15     ISSN:  0160-564X     ISO Abbreviation:  Artif Organs     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-04-03     Completed Date:  1991-04-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2-4     Citation Subset:  IM    
Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611.
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MeSH Terms
Anaphylaxis / etiology,  immunology*
Enzyme-Linked Immunosorbent Assay
Immunoglobulin E / immunology*
Immunoglobulin G / immunology*
Peritoneal Dialysis
Renal Dialysis / adverse effects*
Toluene 2,4-Diisocyanate / immunology*
Grant Support
Reg. No./Substance:
0/Immunoglobulin G; 37341-29-0/Immunoglobulin E; 584-84-9/Toluene 2,4-Diisocyanate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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