Document Detail

Antibodies to silicone elastomers and reactions to ventriculoperitoneal shunts.
MedLine Citation:
PMID:  1354277     Owner:  NLM     Status:  MEDLINE    
Silicone elastomers used to make medical implants and prostheses are generally believed to be biologically inert. However, we have seen two patients who showed severe, apparently immunemediated, reactions to ventriculoperitoneal (VP) shunts. We used an enzyme-linked immunosorbent assay in which Silastic tubing served as the solid-phase antigen to test serum from the two patients, five other VP shunt patients without inflammatory reactions, and nine healthy adults. IgG binding to Silastic tubing was consistently higher in the two patients than in the healthy or patient controls. The IgG seemed to be binding specifically, since IgG Fab fragments also bound to the tubing, and preincubation of serum with Silastic or silylated proteins removed most of the activity. These findings show that specific immune reactivity to elastomers of polydimethylsiloxane can develop in human beings.
R M Goldblum; R P Pelley; A A O'Donell; D Pyron; J P Heggers
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Lancet     Volume:  340     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-09-17     Completed Date:  1992-09-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  510-3     Citation Subset:  AIM; IM    
Department of Pediatrics, University of Texas Medical Branch, Galveston 77550.
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MeSH Terms
Cerebrospinal Fluid Shunts / adverse effects*
Child, Preschool
Foreign-Body Reaction / etiology*,  immunology
Immunoglobulin G / biosynthesis
Peritoneum / surgery
Silicone Elastomers / adverse effects*
Reg. No./Substance:
0/Immunoglobulin G; 0/Silicone Elastomers
Erratum In:
Lancet 1992 Sep 26;340(8822):800

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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