Document Detail


Antibodies to ribonucleic acids detected by ELISA in systemic lupus erythematosus, systemic sclerosis and rheumatoid arthritis.
MedLine Citation:
PMID:  2418204     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The natural and synthetic antiribonucleic acid antibodies (anti-RNA) are more frequently found in systemic lupus erythematosus (SLE) (80%) than in systemic sclerosis (66%) or in rheumatoid arthritis (RA) (54.5%). SLE sera contain antibodies directed against a broader variety of RNA than systemic sclerosis sera and most RA sera. Fifty-two percent of SLE and 29.2% of systemic sclerosis sera recognized at least 5 of the 7 RNA types studied, whereas RA sera recognized only one or 2. Synthetic antipolynucleotide antibody activities are mainly antipolyriboguanylic-ribocytidylic acid (prG-rC), antipolyriboadenylic-ribouridylic acid (prA-rU) and polyriboadenylic acid (prA) antibody in SLE, antipolyriboguanylic acid (prG) and antipolyribocytidylic acid (prC) antibody in systemic sclerosis and anti-prG-rC, anti-prC antibody in RA.
Authors:
O Costa; K Pinatel; J C Monier
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  12     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1986-03-06     Completed Date:  1986-03-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  928-33     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Arthritis, Rheumatoid / immunology
Autoantibodies / analysis*
Autoimmune Diseases / immunology*
Cross Reactions
Enzyme-Linked Immunosorbent Assay
Humans
Lupus Erythematosus, Systemic / immunology
RNA / chemical synthesis,  immunology*
Scleroderma, Systemic / immunology
Chemical
Reg. No./Substance:
0/Autoantibodies; 63231-63-0/RNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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