Document Detail

Antibodies to quail erythrocytes in quail-chicken spinal cord chimeras.
MedLine Citation:
PMID:  8563487     Owner:  NLM     Status:  MEDLINE    
Quail-chicken spinal cord chimeras are a model for temporary acceptance followed by rejection of xenografts and also for demyelinating lesions of the central nervous system. The antiglobulin test with quail erythrocytes was employed to detect antibodies in sera of quail-chicken spinal cord chimeras. Sera of all 46 chimeras tested gave positive results. In virtually all instances, antibodies were detected within 10 weeks after hatching and they persisted for all the observation time up to 8 months. The antibodies detected in these tests were directed against species antigens of the quail. They were apparently identical with xenoantibodies described in a previous study, which were detected by indirect immunofluorescence with quail tissue sections; on the other hand, mixed agglutination tests with quail embryonal cell monolayers employed previously had detected a broader spectrum of antibodies that did the antiglobulin tests with quail erythrocytes. The antiglobulin test with quail erythrocytes seems the most cost-efficient and convenient test to monitor xenoantibody formation in this animal model.
K Saito; G Yang; T Sugisaki; F Milgrom; B Albini
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International archives of allergy and immunology     Volume:  109     ISSN:  1018-2438     ISO Abbreviation:  Int. Arch. Allergy Immunol.     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-03-01     Completed Date:  1996-03-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9211652     Medline TA:  Int Arch Allergy Immunol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  127-32     Citation Subset:  IM    
Department of Microbiology, State University of New York at Buffalo 14214, USA.
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MeSH Terms
Agglutination Tests
Antibodies / blood,  immunology*
Antibody Specificity
Chick Embryo
Chimera / physiology*
Coombs' Test
Erythrocytes / immunology*
Graft Rejection / immunology
Spinal Cord / immunology*,  transplantation
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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