Document Detail


Antibodies to prothrombin in patients with Sneddon's syndrome.
MedLine Citation:
PMID:  10408567     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Antiprothrombin antibodies (aPT), a new serologic marker of antiphospholipid syndrome, were studied in 46 patients randomly selected from 73 with Sneddon's syndrome and 20 matched normal controls. aPT were elevated in 26 patients (57%) and were not found in any of the controls. The addition of aPT data increased the proportion of Sneddon's syndrome patients with at least one type of antiphospholipid syndrome marker from 65 to 78%. The finding that aPT are common in Sneddon's syndrome supports the hypothesis that Sneddon's syndrome is a form of antiphospholipid syndrome.
Authors:
L A Kalashnikova; A D Korczyn; S Shavit; O Rebrova; T Reshetnyak; J Chapman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurology     Volume:  53     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-08-09     Completed Date:  1999-08-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  223-5     Citation Subset:  AIM; IM    
Affiliation:
Institute of Neurology, Moscow, Russia.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antiphospholipid Syndrome / complications,  immunology
Autoantibodies / blood*
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunoglobulin G / blood*
Male
Middle Aged
Prothrombin / immunology*
Reference Values
Sneddon Syndrome / blood,  complications,  immunology*
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Immunoglobulin G; 9001-26-7/Prothrombin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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