Document Detail


Antibodies to pituitary surface antigens during various pituitary disease states.
MedLine Citation:
PMID:  12429039     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Autoantibodies to cell surface antigens of human somatotropinoma (ASAS), human prolactinoma (ASAP) and rat adenohypophysis (ASARA) were assayed in the serum of patients with pituitary diseases associated with GH deficiency (GHD), such as pituitary dwarfism and primary empty sella syndrome (ESS), and in the serum of patients with hyperprolactinaemia of different etiologies: idiopathic hyperprolactinaemia, prolactinoma and ESS. The investigation was carried out with a cellular variant of an ELISA. Among children with GHD, the highest percentage of antibody-positive patients was found in the group with idiopathic isolated GHD (89% of ASAS(+) patients and 30% of ASARA(+) patients vs 33.3% and 0% respectively in the group with idiopathic combined pituitary hormone deficiency, and 33.3% and 9% in patients with pituitary hypoplasia associated with isolated GHD or combined pituitary hormone deficiency). Among hyperprolactinaemic patients, the highest ASAP and ASARA frequency was observed in patients with idiopathic hyperprolactinaemia (67.7% and 41.9% respectively) where it was twice as high as in the group of patients with prolactinoma. The proportion of ASAS(+) and ASARA(+) did not differ significantly between the groups of patients with ess with or without GHD. Similarly, there was no significant difference between the number of ESS ASAP(+) and ASARA(+) patients with or without hyperprolactinaemia. The data obtained suggested that autoimmune disorders may be primary, and responsible, at least in part, for pituitary dysfunction in the cases of idiopathic isolated GHD and idiopathic hyperprolactinaemia. At the same time, the autoimmune disorders in the patients with prolactinoma or ESS are probably secondary to the organic pituitary lesion and their significance in the development of the pituitary dysfunction is obscure.
Authors:
Y M Keda; I V Krjukova; I A Ilovaiskaia; M S Morozova; O V Fofanova; M B Babarina; E I Marova; Y A Pankov; V I Kandror
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of endocrinology     Volume:  175     ISSN:  0022-0795     ISO Abbreviation:  J. Endocrinol.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-13     Completed Date:  2003-01-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375363     Medline TA:  J Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  417-23     Citation Subset:  IM    
Affiliation:
Laboratory of Molecular Endocrinology, Institute of Experimental Endocrinology, Research Centre for Endocrinology, Moscow, Russia. bik181936@mtu-net.ru
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Animals
Antigens, Surface / immunology
Autoantibodies / analysis*,  immunology
Child
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Female
Growth Hormone / deficiency*,  immunology
Human Growth Hormone / immunology
Humans
Hyperprolactinemia / immunology
Male
Pituitary Gland / immunology*
Pituitary Gland, Anterior / immunology
Pituitary Neoplasms / immunology*
Prolactinoma / immunology
Rats
Chemical
Reg. No./Substance:
0/Antigens, Surface; 0/Autoantibodies; 12629-01-5/Human Growth Hormone; 9002-72-6/Growth Hormone

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