Document Detail


Antibodies to oxidized LDL predict coronary artery disease in type 1 diabetes: a nested case-control study from the Pittsburgh Epidemiology of Diabetes Complications Study.
MedLine Citation:
PMID:  10389853     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pathogenesis of excess cardiovascular risk in type 1 diabetes is unclear. LDL cholesterol is only weakly predictive, and its concentration is often normal in type 1 diabetes. We therefore examined whether markers of LDL oxidation such as antibodies to oxidized LDL (Ab-OxLDL) and LDL-containing immune complexes, rather than LDL concentration, were predictive of coronary artery disease (CAD) in type 1 diabetes. This nested case-control study from an epidemiologic cohort study included 49 incident cases of myocardial infarction (MI), angina, or CAD death and 49 age-, sex-, and duration-matched control subjects. Ab-OxLDL was measured by enzyme immunoassay and the apolipoprotein B (ApoB) content of immune complexes (ApoB-IC) precipitated by polyethylene glycol by immunoelectrophoresis in baseline stored samples. Ab-OxLDL was inversely, and ApoB-IC directly, related to subsequent CAD. In multivariate analyses, Ab-OxLDL remained a significant independent predictor along with previously recognized predictors, hypertension and Beck depression score. In conclusion, oxidation of LDL and the immune response it elicits may play a role in predicting the development of CAD in type 1 diabetes and explain at least some of the enhanced CAD risk in type I diabetes.
Authors:
T J Orchard; G Virella; K Y Forrest; R W Evans; D J Becker; M F Lopes-Virella
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Diabetes     Volume:  48     ISSN:  0012-1797     ISO Abbreviation:  Diabetes     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-07-22     Completed Date:  1999-07-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372763     Medline TA:  Diabetes     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1454-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age of Onset
Case-Control Studies
Child
Coronary Disease / immunology*
Diabetes Mellitus, Type 1 / immunology*
Diabetic Angiopathies / epidemiology,  immunology*
Follow-Up Studies
Glycosylation
Humans
Lipoproteins, LDL / immunology*
Multivariate Analysis
Oxidation-Reduction
Pennsylvania / epidemiology
Risk Factors
Grant Support
ID/Acronym/Agency:
DK 34818/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Lipoproteins, LDL

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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