| Antibodies to histones in systemic lupus erythematosus. | |
| | |
MedLine Citation:
|
PMID: 380854 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Antibodies to histones were investigated in the serum of forty-five patients with spontaneously occurring systemic lupus erythematosus (SLE) who were not receiving any form of treatment. Twenty-three had active and twenty-two had inactive disease. Thos with active disease were also studied after the initiation of corticosteroid treatment to determine the effect of treatment on anti-histone antibodies. Both a complement fixation method and indirect immunofluorescence of acid-eluted histone-reconstituted tissue sections were used, with excellent correlation between these two methods. Eleven of the forty-five SLE patients, but none of forty-five normal controls had antibodies to histone. Untreated patients with active and inactive disease had a similar incidence of antibodies to histone. They disappeared, however, soon after the initiation of treatment in the patients with active disease. Patients with antibodies to histones had a higher prevalence of cutaneous vasculitis, anaemia, lupus nephropathy and Raynaud's phenomenon, but a lower prevalence of lupus brain involvement than those without such antibodies. Only the latter, however, reached statistical significance. |
| | |
Authors:
|
E Fishbein; D Alarcon-Segovia; J M Vega |
Related Documents
:
|
19825274 - The clinical significance of microembolic signals in patients with systemic lupus eryth... 1580864 - Mortality in systemic lupus erythematosus: active disease is the most important factor. 3237704 - Vascular lesions in lupus nephritis. 17367224 - Association of rosacea with demodicosis. 22720304 - Reassessment of the role of methane production between irritable bowel syndrome and fun... 15971424 - Diagnosis delay in familial mediterranean fever (fmf): social and gender gaps disclosed. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Clinical and experimental immunology Volume: 36 ISSN: 0009-9104 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 1979 Apr |
Date Detail:
|
Created Date: 1979-10-17 Completed Date: 1979-10-17 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 145-50 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenal Cortex Hormones
/
therapeutic use Antibodies, Antinuclear / analysis* Complement Fixation Tests Fluorescent Antibody Technique Histones / immunology* Humans Lupus Erythematosus, Systemic / complications, drug therapy, immunology* |
| Chemical | |
Reg. No./Substance:
|
0/Adrenal Cortex Hormones; 0/Antibodies, Antinuclear; 0/Histones |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Research in leprosy. A report of a committee set up by the medical research council to study future ...
Next Document: The kinetics and quality of acquired resistance in self-healing and metastatic leishmaniasis.