Document Detail


Antibodies to endothelial cells in borderline hypertension.
MedLine Citation:
PMID:  9736596     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Antibodies to endothelial cells (aECs) and to cardiolipin (aCLs) are implicated in autoimmune diseases like systemic lupus erythematosus vasculitis. Beta2-Glycoprotein 1 (beta2GP1) is a cofactor for aCLs. The present study investigated the possible role of aECs, aCLs, and abeta2GP1 in borderline hypertension. METHODS AND RESULTS: Seventy-three men with borderline hypertension (BHT) and 73 age-matched normotensive (NT) men (diastolic blood pressure, 85 to 94 and <80 mm Hg, respectively) were recruited from a population screening program. Antibody levels were determined by ELISA. Presence of carotid atherosclerosis was determined by B-mode ultrasonography, and 29 individuals had atherosclerotic plaques. BHT men had significantly higher aEC and abeta2GP1 levels of IgG class than NT control subjects (P=0.029 and P=0.0001, respectively). aEC levels of IgM class were higher in BHT (P=0.012), but not abeta2GP1 levels. There was no correlation between aCL levels and BHT. Individuals with atherosclerotic plaques had significantly higher aEC levels of both IgG (P=0.042) and IgM subclasses (P=0.018) than those without plaques, but no difference was found in aCL and abeta2GP1 levels. Endothelin and aECs of IgM class were significantly associated. CONCLUSIONS: We demonstrate the first evidence of a significant elevation of aEC and abeta2GP1 levels in borderline hypertension. These findings provide a new link between hypertension and atherosclerosis and indicate that humoral immune reactions to the endothelium may play an important role in both conditions.
Authors:
J Frostegård; R Wu; C Gillis-Haegerstrand; C Lemne; U de Faire
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulation     Volume:  98     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-10-01     Completed Date:  1998-10-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1092-8     Citation Subset:  AIM; IM    
Affiliation:
From the Department of Medicine, Unit of Rheumatology, Karolinska Hospital and Center of Molecular Medicine; the Department of Thoracic and Cardiovascular Surgery, Karolinska Hospital the Department of Medicine, Stockholm, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adult
Apolipoproteins / blood,  immunology
Arteriosclerosis / immunology*
Blood Pressure
Carotid Artery Diseases / pathology,  ultrasonography
Cross Reactions
Endothelin-1 / blood
Endothelium, Vascular / chemistry,  immunology*,  metabolism
Glycoproteins / immunology
Humans
Hypertension / immunology*
Immunoglobulin G / blood
Immunoglobulin M / blood
Insulin-Like Growth Factor Binding Protein 1 / blood
Male
Middle Aged
beta 2-Glycoprotein I
Chemical
Reg. No./Substance:
0/Apolipoproteins; 0/Endothelin-1; 0/Glycoproteins; 0/Immunoglobulin G; 0/Immunoglobulin M; 0/Insulin-Like Growth Factor Binding Protein 1; 0/beta 2-Glycoprotein I

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