| Antibodies to cytokeratin filaments in patients with alcoholic liver disease. | |
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MedLine Citation:
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PMID: 6203426 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous studies have suggested that cytoskeletal elements in an altered form in vivo (alcoholic hyalin , AH) are targets for an autoimmune reaction in alcoholic liver disease (ALD). In this study we assayed autoantibodies to cytoskeletal cytoskeletal cytokeratin filaments, intermediate filaments of epithelial cells, by indirect immunofluorescence technique (IIF) using cultured human amnion epithelial cells and PtK 2 cells as targets. Sera from 20 patients with ALD, 38 patients with urogenital cancer, 22 patients with renal diseases, and from 18 healthy controls were studied. Patients with ALD had a significantly increased prevalence of cytokeratin filament autoantibodies using both PtK 2 cells (69%) and human amnion epithelial cells (69%) as substrate, as compared to other groups. The antibodies were mainly of IgA and IgM class and could be demonstrated in all forms of ALD. Interestingly, cytoskeleton antibodies have previously been observed in diseases of viral and "autoimmune" origin. |
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Authors:
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P Kurki; I Virtanen; V P Lehto; O Alfthan; M Salaspuro |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Alcoholism, clinical and experimental research Volume: 8 ISSN: 0145-6008 ISO Abbreviation: Alcohol. Clin. Exp. Res. Publication Date: 1984 Mar-Apr |
Date Detail:
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Created Date: 1984-07-05 Completed Date: 1984-07-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7707242 Medline TA: Alcohol Clin Exp Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 212-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Autoantibodies / analysis* Cytoskeleton / immunology* Female Fluorescent Antibody Technique Humans Keratins / immunology* Liver Diseases, Alcoholic / immunology* Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 68238-35-7/Keratins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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