Document Detail

Antibodies to citrullinated peptides and risk of coronary heart disease.
MedLine Citation:
PMID:  23474125     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Increased cardiovascular risk has been associated with high levels of serum antibodies to citrullinated proteins (ACPA) in patients with rheumatoid arthritis (RA). Citrullination is part of many chronic inflammatory processes and we therefore investigated whether ACPA might be associated with coronary artery disease, in the absence of RA.
METHODS: To maximize the potential predictive value of this retrospective study we included sera from a cohort of 3052 healthy male individuals, subsequently followed for the development of coronary artery disease, and documented for other disease risk factors. With each case event (myocardial infarction; n = 144), 2 matched controls were assigned.
RESULTS: We found 10.4% of cases were ACPA positive compared to 3.8% of controls (odds ratio (95% CI) = 3.26 (1.36-7.80), p = 0.008), remaining significant after adjustment for classical risk factors including smoking and CRP (4.23 (1.22-14.61) p = 0.02).
CONCLUSION: The genesis and fine specificity of ACPA in patients with atherosclerosis, in the absence of Rheumatoid arthritis, may prove worthy of further investigation.
Geraldine Cambridge; Jayshree Acharya; Jackie A Cooper; Jonathan C Edwards; Steve E Humphries
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-02-18
Journal Detail:
Title:  Atherosclerosis     Volume:  228     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-29     Completed Date:  2013-11-05     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  243-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Arthritis, Rheumatoid / epidemiology
Autoantibodies / blood*
Coronary Artery Disease / epidemiology*,  immunology*
Immunoglobulin A / blood
Immunoglobulin G / blood
Immunoglobulin M / blood
Logistic Models
Middle Aged
Peptides, Cyclic / immunology*
Retrospective Studies
Risk Factors
Seroepidemiologic Studies
Vasculitis / epidemiology,  immunology
Grant Support
NHLBI 33014//PHS HHS; PG08/008//British Heart Foundation; RG/08/008/25291//British Heart Foundation; //Medical Research Council
Reg. No./Substance:
0/Autoantibodies; 0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin M; 0/Peptides, Cyclic; 0/cyclic citrullinated peptide

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