Document Detail


Antibodies to acetylcholine receptors in myasthenia gravis. In vitro synthesis by peripheral blood lymphocytes before and after thymectomy.
MedLine Citation:
PMID:  1735188     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pokeweed mitogen (PWM)-driven in vitro synthesis of antibodies to the acetylcholine receptor (PSA) was studied in non-thymoma patients with myasthenia gravis. In a group of 46 patients, the occurrence of PSA was related to the presence of the thymus or, in operated patients, the absence of a clinical effect of thymectomy. Sixteen patients were followed before and soon after thymectomy. PSA disappeared in all patients, at least temporarily, between 6 weeks and 1 year afterwards, independent of the clinical course and eventual clinical effect of the operation. A recurrence was found only in one of the five patients who derived no benefit from the operation. These findings support the hypothesis that the therapeutic effect of thymectomy can be explained by removal of a source of autoreactive lymphocytes. There was no correlation between the changes in serum levels of a-AChR and clinical improvement, suggesting a minor role of circulating peripheral blood lymphocytes (PBL) and the thymus in the total production of a-AChR.
Authors:
J B Kuks; P C Limburg; H J Oosterhuis; T H The
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  87     ISSN:  0009-9104     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-03-12     Completed Date:  1992-03-12     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  246-50     Citation Subset:  IM    
Affiliation:
Department of Neurology, University Hospital, Groningen, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antibody Formation / drug effects
Autoantibodies / immunology*
B-Lymphocytes / metabolism
Cells, Cultured
Cross-Sectional Studies
Female
Humans
Longitudinal Studies
Male
Myasthenia Gravis / immunology*,  surgery
Pokeweed Mitogens / administration & dosage
Receptors, Nicotinic / immunology*
Thymectomy
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Pokeweed Mitogens; 0/Receptors, Nicotinic
Comments/Corrections

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