Document Detail

Antibodies to Ureaplasma urealyticum in women with intraamniotic infection and adverse pregnancy outcome.
MedLine Citation:
PMID:  7900509     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the association between antibody response to Ureaplasma urealyticum and pregnancy outcome in women with ureaplasmal invasion of the amniotic cavity. METHODS: A cross section study was performed in our high risk pregnancy unit. Three groups of pregnant women were identified: 1) 271 women at the midtrimester of pregnancy (16-20 weeks), who underwent transabdominal amniocentesis for genetic indications 2) 161 consecutive women admitted with preterm labor and intact membranes. 3) 118 consecutive patients with preterm premature rupture of membranes. Amniotic fluids were cultured for Ureaplasma urealyticum, Mycoplasma hominis and also for other aerobic and anaerobic bacteria. Serum antibodies to Uu were measured by a specific enzyme-linked-immunosorbent-assay. RESULTS: The prevalence of positive AF cultures with Uu in the 3 study groups was 2.9%, 4.3% and 17.8%, and the prevalence of antibodies to Uu in the AF-colonized patients was 50%, 86% and 57%, respectively. Adverse pregnancy outcome (preterm birth, low birth weight or fetal death) among all AF colonized women, was significantly higher in patients with antibodies to Uu than in those without antibodies; preterm delivery 90% vs. 43%, and low birth weight infants or fetal death 85% vs. 28%, p = 0.006 and 0.001 respectively. CONCLUSION: Women with intraamniotic infection with Uu and elevated levels of antibodies to Uu, had a higher rate of preterm delivery, and low birthweight infants/fetal death than those without antibody to Uu.
S Horowitz; M Mazor; J Horowitz; A Porath; M Glezerman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  74     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-04-25     Completed Date:  1995-04-25     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  132-6     Citation Subset:  IM    
Department of Microbiology and Immunology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Soroka Medical Center of Kupat-Holim, Beer-Sheva, Israel.
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MeSH Terms
Amniotic Fluid / immunology*,  microbiology
Antibodies, Bacterial / immunology*
Cross-Sectional Studies
Fetal Diseases / diagnosis,  immunology*,  microbiology
Fetal Membranes, Premature Rupture / diagnosis,  immunology*,  microbiology
Middle Aged
Obstetric Labor, Premature*
Pregnancy Complications, Infectious / diagnosis,  immunology*,  microbiology
Pregnancy Outcome*
Ureaplasma Infections / diagnosis,  immunology*,  microbiology
Ureaplasma urealyticum / immunology*,  isolation & purification
Reg. No./Substance:
0/Antibodies, Bacterial

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