Document Detail

Antibodies to Klebsiella pneumoniae, Escherichia coli and Proteus mirabilis in the sera of ankylosing spondylitis patients with/without iritis and enthesitis.
MedLine Citation:
PMID:  7788169     Owner:  NLM     Status:  MEDLINE    
IgM, IgG and IgA class serum antibodies against the whole Klebsiella pneumoniae, Escherichia coli and Proteus mirabilis bacteria, as well as against K. pneumoniae and E. coli lipopolysaccharides (LPSs) were studied earlier in the sera of 98 patients with ankylosing spondylitis (AS) and in 102 healthy blood donors by enzyme immunoassay. In this study the patients were divided into groups according to the clinical picture, i.e. presence or absence of iritis and enthesitis. The previous major finding of increased IgA class antibody levels against the whole K. pneumoniae bacteria in AS patients when compared to the healthy controls was not specifically associated with any single patient group in the present study. However, the patients with iritis had higher levels of IgA class antibodies to LPS of K. pneumoniae and E. coli when compared to the patients without iritis. In addition, the patients without enthesitis had higher level of IgG class antibodies against whole K. pneumoniae bacteria compared to the patients with enthesitis. The increased IgA class antibody levels against K. pneumoniae and E. coli LPS in AS patients with iritis may reflect an inflammatory process in the gut area. Furthermore, there were certain other differences in the immunological parameters between the AS patients with and without iritis or enthesitis and the possibility that they reflect different mechanisms involved in the disease processes cannot be excluded.
O Mäki-Ikola; K Lehtinen; P Toivanen; K Granfors
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of rheumatology     Volume:  34     ISSN:  0263-7103     ISO Abbreviation:  Br. J. Rheumatol.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-07-27     Completed Date:  1995-07-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8302415     Medline TA:  Br J Rheumatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  418-20     Citation Subset:  AIM; IM    
National Public Health Institute, Department in Turku, Finland.
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MeSH Terms
Antibodies, Bacterial / blood*
Enzyme-Linked Immunosorbent Assay
Escherichia coli / immunology*
Immunoglobulin A / blood
Immunoglobulin G / blood
Immunoglobulin M / blood
Iritis / complications,  immunology*
Klebsiella pneumoniae / immunology*
Lipopolysaccharides / immunology
Proteus mirabilis / immunology*
Spondylitis, Ankylosing / complications,  immunology*
Tendinopathy / complications,  immunology*
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin M; 0/Lipopolysaccharides

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