| Antibodies to chondroitin sulfate A-binding infected erythrocytes: dynamics and protection during pregnancy in women receiving intermittent preventive treatment. | |
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MedLine Citation:
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PMID: 20350189 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Plasmodium falciparum parasites that cause malaria in pregnancy express unique variant surface antigens (VSAs). Levels of immunoglobulin G (IgG) antibody to pregnancy-associated VSAs measured at delivery are gravidity dependent, and they have been associated with protection from disease. It is not known how these IgG responses develop in pregnant women receiving intermittent preventive treatment during pregnancy (IPTp) or whether IgG levels in early pregnancy predict pregnancy outcomes. METHODS: We performed longitudinal measurements of IgG antibody to VSAs by flow cytometric analysis of serum samples obtained from 549 Malawian women receiving IPTp. We examined fluctuations in IgG levels over time and associated the IgG levels noted at study enrollment with clinical outcomes. RESULTS: Levels of IgG antibody to pregnancy-associated VSAs were gravidity dependent. Overall, levels decreased while women were receiving IPTp, but the levels of the individuals were highly dynamic. Primigravidae developed low levels of pregnancy-specific IgG, which were often boosted during second pregnancies. The prevalence of parasites was low (8.4% at enrollment and 2.4% in late pregnancy). Antibody levels at enrollment did not predict birth weight, duration of gestation at delivery, or the maternal hemoglobin level in late pregnancy. CONCLUSION: Levels of IgG antibody to pregnancy-specific VSAs decrease during receipt of IPTp. Antibody levels in early pregnancy did not predict clinical outcome. IPTp and decreasing malaria prevalence pose challenges for the evaluation of novel interventions for malaria during pregnancy. |
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Authors:
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Elizabeth H Aitken; Bernard Mbewe; Mari Luntamo; Ken Maleta; Teija Kulmala; Marc-James Friso; Freya J I Fowkes; James G Beeson; Per Ashorn; Stephen J Rogerson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 201 ISSN: 1537-6613 ISO Abbreviation: J. Infect. Dis. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-06 Completed Date: 2010-04-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 1316-25 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Royal Parade, Parkville, Victoria 3052, Australia. e.aitken@ugrad.unimelb.edu.au |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00131235 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antibodies, Protozoan / blood*, immunology Antigens, Surface / immunology Antimalarials / administration & dosage, therapeutic use* Chondroitin Sulfates / metabolism* Drug Combinations Erythrocytes / immunology, parasitology Female Humans Immunoglobulin G / blood Longitudinal Studies Malaria, Falciparum / immunology, prevention & control* Malawi Parity Plasmodium falciparum / immunology* Pregnancy Pregnancy Complications, Parasitic / immunology, prevention & control* Pyrimethamine / administration & dosage, therapeutic use* Sulfadoxine / administration & dosage, therapeutic use* Treatment Outcome Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Protozoan; 0/Antigens, Surface; 0/Antimalarials; 0/Drug Combinations; 0/Immunoglobulin G; 2447-57-6/Sulfadoxine; 37338-39-9/sulfadoxine-pyrimethamine; 58-14-0/Pyrimethamine; 9007-28-7/Chondroitin Sulfates |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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