Document Detail

Antibodies to Bacteroides gingivalis in patients with treated and untreated periodontal disease.
MedLine Citation:
PMID:  2656978     Owner:  NLM     Status:  MEDLINE    
It is proposed that the development of periodontal disease is associated with rising levels of serum and gingival crevice fluid (GCF) IgG antibodies to specific organisms, while treatment of periodontal disease is associated with a decline in specific IgG antibodies. This study examined the immune response to Bacteroides gingivalis, a suspected periodontal pathogen, in serum and GCF of patients with adult periodontitis. Three groups of subjects were studied: (1) patients with untreated adult periodontitis, (2) patients with treated adult periodontitis, and (3) patients with gingivitis (controls). An enzyme-linked immunosorbent assay was employed using whole formalinized B. gingivalis (ATCC 33277) as antigen. Results showed that the untreated adult periodontitis patients had a humoral immune response to B. gingivalis, producing significantly higher serum levels of IgG antibody to that organism than did patients with treated adult periodontitis (p less than or equal to 0.01) or gingivitis (p less than or equal to 0.005). The untreated patients also demonstrated a local immune response to B. gingivalis in that their GCF levels of IgG antibody to that organism were also significantly higher than levels in treated adult periodontitis patients (p less than or equal to 0.005) and gingivitis patients (p less than or equal to 0.001). These results are consistent with reports by other investigators. However, ratios of GCF antibody to serum antibody in the untreated adult periodontitis group were not significantly higher than ratios in the other two groups.(ABSTRACT TRUNCATED AT 250 WORDS)
P A Murray; D A Burstein; J R Winkler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of periodontology     Volume:  60     ISSN:  0022-3492     ISO Abbreviation:  J. Periodontol.     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-06-30     Completed Date:  1989-06-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8000345     Medline TA:  J Periodontol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  96-103     Citation Subset:  D; IM    
Department of Stomatology, School of Dentistry, University of California, San Francisco.
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MeSH Terms
Antibodies, Bacterial / analysis*
Antigens, Bacterial / analysis
Bacteroides / immunology*
Blotting, Western
Electrophoresis, Polyacrylamide Gel
Gingival Crevicular Fluid / immunology
Gingivitis / immunology,  microbiology*
Immunoglobulin G / analysis*
Middle Aged
Periodontitis / immunology,  microbiology*,  therapy
Grant Support
507 RR 05305/RR/NCRR NIH HHS
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Antigens, Bacterial; 0/Immunoglobulin G

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