Document Detail


Antibodies to the 4-mer repeat of the ring-infected erythrocyte surface antigen (Pf155/RESA) protect against Plasmodium falciparum malaria.
MedLine Citation:
PMID:  7515035     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To investigate the protective role of antibodies to the ring-infected erythrocyte surface antigen (Pf155/RESA) epitopes against Plasmodium falciparum clinical malaria, a cohort study was conducted in a Malagasy village over 7 months. In the 304 individuals included, 127 experienced P. falciparum attacks of under 1500 parasites/microliters with no clinical symptoms (protected individuals) and 177 experienced at least one clinical or preclinical P. falciparum attack requiring therapy (unprotected individuals). Antibodies to whole Pf155/RESA, to single epitopes of the 3' terminus, (EENV)4 and EENVEHDA(EENV)2 had higher responses in protected than in unprotected individuals (P = 0.006, P = 0.005, P = 0.05 respectively). Within the whole pattern of antibodies to the Pf155/RESA epitopes, only anti-R4 was related to protection independently of age and anti-wR. The Pf155/RESA 4-mer repeated epitope might be of interest for inclusion in a vaccine against the asexual blood stages of P. falciparum.
Authors:
P Astagneau; C Chougnet; J P Lepers; M Danielle; M D Andriamangatiana-Rason; P Deloron
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of epidemiology     Volume:  23     ISSN:  0300-5771     ISO Abbreviation:  Int J Epidemiol     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-06-28     Completed Date:  1994-06-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7802871     Medline TA:  Int J Epidemiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  169-75     Citation Subset:  IM    
Affiliation:
INSERM Unité 13, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Amino Acid Sequence
Animals
Antibodies, Protozoan / biosynthesis*,  isolation & purification
Antigens, Protozoan / chemistry,  immunology*
Antigens, Surface / chemistry,  immunology*
Child
Child, Preschool
Cohort Studies
Epitopes / chemistry
Follow-Up Studies
Humans
Incidence
Infant
Madagascar / epidemiology
Malaria, Falciparum / epidemiology*,  immunology*
Molecular Sequence Data
Plasmodium falciparum / immunology*
Prevalence
Protozoan Proteins / chemistry,  immunology*
Chemical
Reg. No./Substance:
0/Antibodies, Protozoan; 0/Antigens, Protozoan; 0/Antigens, Surface; 0/Epitopes; 0/Protozoan Proteins; 0/ring-infected erythrocyte surface antigen (RESA), Plasmodium falciparum

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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