| Antibodies to 125I-glutamic acid decarboxylase in patients with stiff man syndrome. | |
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MedLine Citation:
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PMID: 9120459 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Antibodies to glutamic acid decarboxylase (GAD) are found in about 40% of patients with stiff man syndrome. A new assay involving immunoprecipitation of (125)I-glutamic acid decarboxylase was used to measure anti-GAD antibodies in 18 patients with stiff man syndrome. Of the eight serum samples from patients with stiff man syndrome, that had previously been found positive by immunoprecipitation of (35)S-GAD, seven were strongly positive with (125)I-GAD and one gave an equivocal result. Other serum samples from patients with stiff man syndrome and from controls were negative except one from a patient who had a thymoma, acquired neuromyotonia, and myasthenia gravis. Nine of 35 serum samples referred for testing were positive; in two of these the serum titre was 20-50 times higher than that in the CSF. This assay should prove useful in the diagnosis, management, and investigation of stiff man syndrome. |
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Authors:
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A Vincent; L M Grimaldi; G Martino; C Davenport; I Todd |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neurology, neurosurgery, and psychiatry Volume: 62 ISSN: 0022-3050 ISO Abbreviation: J. Neurol. Neurosurg. Psychiatr. Publication Date: 1997 Apr |
Date Detail:
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Created Date: 1997-04-24 Completed Date: 1997-04-24 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2985191R Medline TA: J Neurol Neurosurg Psychiatry Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 395-7 Citation Subset: IM |
Affiliation:
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Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies
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blood*,
cerebrospinal fluid Female Glutamate Decarboxylase / immunology* Humans Stiff-Person Syndrome / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; EC 4.1.1.15/Glutamate Decarboxylase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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