| Antibodies protect against intracellular bacteria by Fc receptor-mediated lysosomal targeting. | |
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MedLine Citation:
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PMID: 21048081 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The protective effect of antibodies (Abs) is generally attributed to neutralization or complement activation. Using Legionella pneumophila and Mycobacterium bovis bacillus Calmette-Guérin as a model, we discovered an additional mechanism of Ab-mediated protection effective against intracellular pathogens that normally evade lysosomal fusion. We show that Fc receptor (FcR) engagement by Abs, which can be temporally and spatially separated from bacterial infection, renders the host cell nonpermissive for bacterial replication and targets the pathogens to lysosomes. This process is strictly dependent on kinases involved in FcR signaling but not on host cell protein synthesis or protease activation. Based on these findings, we propose a mechanism whereby Abs and FcR engagement subverts the strategies by which intracellular bacterial pathogens evade lysosomal degradation. |
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Authors:
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Nicole Joller; Stefan S Weber; Andreas J Müller; Roman Spörri; Petra Selchow; Peter Sander; Hubert Hilbi; Annette Oxenius |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-11-03 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 107 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-24 Completed Date: 2011-01-20 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 20441-6 Citation Subset: IM |
Affiliation:
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Institute for Microbiology, Eidgenössiche Technische Hochschule Zürich, 8093 Zurich, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Bacterial / immunology* Bacterial Infections / immunology* Bacterial Load Immunization Legionella pneumophila Lysosomes / immunology* Mice Microscopy, Fluorescence Mycobacterium bovis Receptors, Fc / immunology* Signal Transduction / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Bacterial; 0/Receptors, Fc |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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