| Antibodies as antigens--idiotypes and idiotypic networks | |
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MedLine Citation:
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PMID: 2479088 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The variable regions of an antibody are unique and therefore potentially immunogenic. This may result in the formation of antiidiotypic antibodies directed against these antigenic determinants. Based on this observation, JERNE has proposed his theory of idiotypic networks. According to this concept, interactions between idiotypes and antiidiotypic antibodies may play an important role in the regulation of the immune response. Idiotypic networks are thought to be essential for the maintenance of immunological tolerance to self-antigens and there is evidence that autoimmunity may in part be due to perturbation of the idiotypic network. Anti-idiotypes may be of therapeutic importance. Although production of idiotypic vaccines or treatment of hematological malignancies with tailored anti-idiotypes are still hampered by various difficulties, a widespread clinical application may be only a matter of time. |
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Authors:
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P Berchtold |
Publication Detail:
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Type: English Abstract; Journal Article; Review |
Journal Detail:
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Title: Schweizerische medizinische Wochenschrift Volume: 119 ISSN: 0036-7672 ISO Abbreviation: Schweiz Med Wochenschr Publication Date: 1989 Nov |
Date Detail:
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Created Date: 1989-12-18 Completed Date: 1989-12-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404401 Medline TA: Schweiz Med Wochenschr Country: SWITZERLAND |
Other Details:
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Languages: ger Pagination: 1577-82 Citation Subset: IM |
Affiliation:
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Medizinische Universitätsklinik, Inselspital, Bern. |
Vernacular Title:
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Antikörper als Antigene--Idiotypen und idiotypische Netzwerke. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies
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immunology* Antibodies, Anti-Idiotypic / biosynthesis*, therapeutic use Autoimmunity Epitopes / immunology Humans Immune Tolerance Immunoglobulin Variable Region / immunology* Isoantigens / immunology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/Antibodies, Anti-Idiotypic; 0/Epitopes; 0/Immunoglobulin Variable Region; 0/Isoantigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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