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Antibodies against β-fibrin synthetic peptides: A study of their association with the immunogenetic background and disease course of rheumatoid arthritis patients.
MedLine Citation:
PMID:  21295379     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Preliminary studies have shown the potential application for the diagnosis of Rheumatoid Arthritis (RA) patients with a severe disease course of an epitopic domain of β-fibrin. The aim of the present work was the analysis of the presence of antibodies against several β-fibrin synthetic peptides in relation to the immunogenetic background and disease course in a clinically well-defined RA patient cohort. Our results indicated that positive patients against anti-β-fibrin synthetic peptides have a higher percentage of HLA-DRB1 shared epitope (SE) than negative patients. We also observed that the presence of SE alleles was significantly associated with a higher level of anti-[Cit(376)]βfib(365-383) antibodies. When analyzing the effect of different SE alleles, we found a significant positive association between carriers of QRRAA allele and [Cit(376)]βfib(365-383) (Odds ratio 3.77; CI95%: 1.41-10.08). These results suggest that the anti-β-fibrin status is associated with the immunogenetic background of RA patients.
Authors:
Isabel Haro; María J Gómara; María L Pérez; Odette Viñas; Guadalupe Ercilla; José A Gómez-Puerta; Raimon Sanmartí
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-21
Journal Detail:
Title:  European journal of medicinal chemistry     Volume:  -     ISSN:  1768-3254     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-2-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0420510     Medline TA:  Eur J Med Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Masson SAS. All rights reserved.
Affiliation:
Unit of Synthesis and Biomedical Applications of Peptides, Department of Biomedical Chemistry, IQAC-CSIC, Jordi Girona, 18-26, Barcelona 08034, Spain.
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