| Antibodies against β-fibrin synthetic peptides: A study of their association with the immunogenetic background and disease course of rheumatoid arthritis patients. | |
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MedLine Citation:
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PMID: 21295379 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Preliminary studies have shown the potential application for the diagnosis of Rheumatoid Arthritis (RA) patients with a severe disease course of an epitopic domain of β-fibrin. The aim of the present work was the analysis of the presence of antibodies against several β-fibrin synthetic peptides in relation to the immunogenetic background and disease course in a clinically well-defined RA patient cohort. Our results indicated that positive patients against anti-β-fibrin synthetic peptides have a higher percentage of HLA-DRB1 shared epitope (SE) than negative patients. We also observed that the presence of SE alleles was significantly associated with a higher level of anti-[Cit(376)]βfib(365-383) antibodies. When analyzing the effect of different SE alleles, we found a significant positive association between carriers of QRRAA allele and [Cit(376)]βfib(365-383) (Odds ratio 3.77; CI95%: 1.41-10.08). These results suggest that the anti-β-fibrin status is associated with the immunogenetic background of RA patients. |
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Authors:
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Isabel Haro; María J Gómara; María L Pérez; Odette Viñas; Guadalupe Ercilla; José A Gómez-Puerta; Raimon Sanmartí |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-21 |
Journal Detail:
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Title: European journal of medicinal chemistry Volume: - ISSN: 1768-3254 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-2-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0420510 Medline TA: Eur J Med Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Masson SAS. All rights reserved. |
Affiliation:
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Unit of Synthesis and Biomedical Applications of Peptides, Department of Biomedical Chemistry, IQAC-CSIC, Jordi Girona, 18-26, Barcelona 08034, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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