| Antibodies against Sporothrix schenckii enhance TNF-α production and killing by macrophages. | |
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MedLine Citation:
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PMID: 21923739 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Sporotrichosis is a chronic granulomatous mycosis caused by the dimorphic fungus Sporothrix schenckii. The immunological mechanisms involved in the prevention and control of sporotrichosis suggest that cell-mediated immunity plays an important role in protecting the host against S. schenckii. Nonetheless, recent data strongly support the existence of protective Abs against this pathogenic fungus. In a previous study, we showed that passive Ab therapy led to a significant reduction in the number of CFU in the organs of mice when the MAb was injected before and during S. schenckii infection. The ability of opsonization to enhance macrophage damage to S. schenckii and subsequent cytokine production was investigated in this work. Here we show that the fungicidal characteristics of macrophages are increased when the fungus is phagocytosed in the presence of inactivated serum from mice infected with S. schenckii or mAb anti-gp70. Additionally, we show an increase in the levels of pro-inflammatory cytokines such as TNF-α and IL-1β. This study provides additional support for the importance of antibodies in protecting against S. schenckii and concludes that opsonization is an important process to increase TNF-α production and fungus killing by macrophages in experimental sporotrichosis. |
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Authors:
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Daniele de Lima Franco; Rosana Cicero Nascimento; Karen Spadari Ferreira; Sandro Rogerio Almeida |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-16 |
Journal Detail:
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Title: Scandinavian journal of immunology Volume: - ISSN: 1365-3083 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0323767 Medline TA: Scand J Immunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Blackwell Publishing Ltd. |
Affiliation:
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Departamento de Análises Clínicas e Toxicológicas - Faculdade de Ciências Farmacêuticas, Universidade de São Paulo Laboratório de Micologia Celular e Proteômica - Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro Departamento de Ciências Biológicas - UNIFESP, Brazil. |
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