Document Detail

Antibiotics and pregnancy.
MedLine Citation:
PMID:  16076072     Owner:  NLM     Status:  MEDLINE    
Like anybody else, pregnant women are susceptible to infections. The correct treatment of these women, however, must consider along with pathogens, the infection site and antibiotic pharmacokinetics, the fetus and possible side effects to the child. When prescribing over this special condition, the physician must remember that the prescription will affect two organism and the drug must treat the mother without affecting the fetus. Beta-lactams having a long history of use without significant deleterious effects on the fetuses still are the safest choice during pregnancy. However, considering the constant increase of multi-resistant microorganisms, the physician has been forced to use different antimicrobial agents. Usually, data regarding safety during pregnancy are very limited, which causes serious doubts during prescription. In addition, many studies regarding the safe use of antibiotics during pregnancy are inconclusive or demand more evidence. The present study is a wide revision regarding the use of antibiotics during pregnancy, considering their pharmacokinetics and the clinical experience in recent years. It also intends to assist the physician during prescription and to give information to the pharmacists to help pregnant women.
F Sá del Fiol; M Gerenutti; F C Groppo
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Die Pharmazie     Volume:  60     ISSN:  0031-7144     ISO Abbreviation:  Pharmazie     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-08-03     Completed Date:  2005-09-14     Revised Date:  2007-01-29    
Medline Journal Info:
Nlm Unique ID:  9800766     Medline TA:  Pharmazie     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  483-93     Citation Subset:  IM    
Pharmacology Department, School of Pharmacy of University of Sorocaba, Campinas State University, UNICAMP, Brazil.
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MeSH Terms
Anti-Bacterial Agents / adverse effects*,  classification,  pharmacokinetics
Bacteria / drug effects,  metabolism
Maternal-Fetal Exchange
Nucleic Acid Synthesis Inhibitors / adverse effects,  pharmacokinetics
Pregnancy / physiology*
Protein Synthesis Inhibitors / adverse effects,  pharmacokinetics
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Nucleic Acid Synthesis Inhibitors; 0/Protein Synthesis Inhibitors

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