Document Detail


Antibiotics do not reduce toothache caused by irreversible pulpitis. Are systematic antibiotics effective in providing pain relief in people who have irreversible pulpitis?
MedLine Citation:
PMID:  16184157     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
DATA SOURCES: Cochrane Oral Health Group Trials Register and the Pain, Palliative Care and Supportive Care Group Trials Register, the Cochrane Central Register of Controlled Trials, Medline and Embase. STUDY SELECTION: Randomised controlled trials (RCT) were included that involved patients over the age of 18 years who had presented with a single tooth with a clinical diagnosis of irreversible pulpitis. DATA EXTRACTION AND SYNTHESIS: Abstracts of studies were independently assessed by two reviewers. The primary outcome was patient-reported pain (intensity/duration) and pain relief measured on a categorical scale in the preoperative phase of irreversible pulpitis. Secondary outcomes were type, dose and frequency of medication required for pain relief. Only one trial was included so pooling of data from studies was not possible and a descriptive summary is presented. RESULTS: One trial of 40 participants was included. There was a close parallel distribution of the pain ratings in both the intervention and placebo groups over the 7-day study period. The between-group differences in sum pain intensity differences for the penicillin group were 6.0+/-10.5, and for placebo 6.0+/-9.5 (P=0.776; differences assessed by Mann-Whitney-Wilcoxon test considered to be statistically significant at P=0.05). The sum pain percussion intensity differences for the penicillin group were 3.5+/-7.5 and placebo 2.0+/-7.0 (P=0.290). There was no significant difference in the mean total number of ibuprofen tablets (P=0.839) and acetaminophen tablets (P=0.325) taken for pain relief in either group over the study period. The administration of penicillin over placebo did not appear to significantly reduce the quantity of analgesic medication taken (P=0.05) for irreversible pulpitis. CONCLUSIONS: This review based on one methodologically sound but low-powered small sample trial, provides some evidence that there is no significant difference in pain relief between individuals who had untreated irreversible pulpitis who did or did not take antibiotics in addition to analgesics.
Authors:
Susan Sutherland
Related Documents :
10708837 - Health-related quality of life using the sf-36 in patients with bipolar disorder compar...
22546797 - High rate composting of herbal pharmaceutical industry solid waste.
11246937 - Static magnetic fields for treatment of fibromyalgia: a randomized controlled trial.
21450627 - Medium-term effects of cardiac rehabilitation in germany: systematic review and meta-an...
16760927 - Effects of risperidone augmentation in patients with treatment-resistant depression: re...
18296827 - Prognosis and prognostic factors in patients with idiopathic dilated cardiomyopathy in ...
Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  Evidence-based dentistry     Volume:  6     ISSN:  1462-0049     ISO Abbreviation:  Evid Based Dent     Publication Date:  2005  
Date Detail:
Created Date:  2005-09-26     Completed Date:  2005-11-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883603     Medline TA:  Evid Based Dent     Country:  England    
Other Details:
Languages:  eng     Pagination:  67     Citation Subset:  -    
Affiliation:
Department of Dentistry, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Comments/Corrections
Comment On:
Cochrane Database Syst Rev. 2005;(2):CD004969   [PMID:  15846738 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Good evidence for effectiveness of analgesics most commonly prescribed by UK dentists. What is the r...
Next Document:  Conclusive support for mechanical nonsurgical pocket therapy in the treatment of periodontal disease...