Document Detail

Antibiotic use and misuse in the neonatal intensive care unit.
MedLine Citation:
PMID:  22341537     Owner:  NLM     Status:  MEDLINE    
Neonatal sepsis causes significant morbidity and mortality, especially in preterm infants. Clinicians are compelled to treat with empiric antibiotics at the first signs of suspected sepsis. Broad-spectrum antibiotics and prolonged treatment with empiric antibiotics are associated with adverse outcomes. Most common neonatal pathogens are susceptible to narrow-spectrum antibiotics. The choice of antibiotic and duration of empiric treatment are strongly associated with center-based risk factors. Clinicians should treat with short courses of narrow-spectrum antibiotics whenever possible, choosing the antibiotics and treatment duration to balance the risks of potentially untreated sepsis against the adverse effects of treatment in infants with sterile cultures.
Nidhi Tripathi; C Michael Cotten; P Brian Smith
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-12-29
Journal Detail:
Title:  Clinics in perinatology     Volume:  39     ISSN:  1557-9840     ISO Abbreviation:  Clin Perinatol     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-20     Completed Date:  2012-06-19     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  7501306     Medline TA:  Clin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  61-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Anti-Bacterial Agents / adverse effects,  therapeutic use*
Drug Administration Schedule
Drug Resistance, Bacterial
Infant, Low Birth Weight
Infant, Newborn
Infant, Newborn, Diseases / drug therapy*
Infant, Premature
Infant, Premature, Diseases / drug therapy
Intensive Care Units, Neonatal
Microbial Sensitivity Tests
Risk Factors
Sepsis / drug therapy*,  microbiology
Grant Support
1K23HD060040-01/HD/NICHD NIH HHS; 1R18AE000028-01/AE/ASPE HHS; K23 HD060040/HD/NICHD NIH HHS; K23 HD060040-04/HD/NICHD NIH HHS; L40 HD069892/HD/NICHD NIH HHS; L40 HD069892-04/HD/NICHD NIH HHS; TL1RR024126/RR/NCRR NIH HHS
Reg. No./Substance:
0/Anti-Bacterial Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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