Document Detail


Antibiotic use and misuse in the neonatal intensive care unit.
MedLine Citation:
PMID:  22341537     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neonatal sepsis causes significant morbidity and mortality, especially in preterm infants. Clinicians are compelled to treat with empiric antibiotics at the first signs of suspected sepsis. Broad-spectrum antibiotics and prolonged treatment with empiric antibiotics are associated with adverse outcomes. Most common neonatal pathogens are susceptible to narrow-spectrum antibiotics. The choice of antibiotic and duration of empiric treatment are strongly associated with center-based risk factors. Clinicians should treat with short courses of narrow-spectrum antibiotics whenever possible, choosing the antibiotics and treatment duration to balance the risks of potentially untreated sepsis against the adverse effects of treatment in infants with sterile cultures.
Authors:
Nidhi Tripathi; C Michael Cotten; P Brian Smith
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-12-29
Journal Detail:
Title:  Clinics in perinatology     Volume:  39     ISSN:  1557-9840     ISO Abbreviation:  Clin Perinatol     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-20     Completed Date:  2012-06-19     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  7501306     Medline TA:  Clin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  61-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / adverse effects,  therapeutic use*
Drug Administration Schedule
Drug Resistance, Bacterial
Humans
Infant, Low Birth Weight
Infant, Newborn
Infant, Newborn, Diseases / drug therapy*
Infant, Premature
Infant, Premature, Diseases / drug therapy
Intensive Care Units, Neonatal
Microbial Sensitivity Tests
Risk Factors
Sepsis / drug therapy*,  microbiology
Grant Support
ID/Acronym/Agency:
1K23HD060040-01/HD/NICHD NIH HHS; 1R18AE000028-01/AE/ASPE HHS; K23 HD060040/HD/NICHD NIH HHS; K23 HD060040-04/HD/NICHD NIH HHS; L40 HD069892/HD/NICHD NIH HHS; L40 HD069892-04/HD/NICHD NIH HHS; TL1RR024126/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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