| Antibiotic use and misuse in the neonatal intensive care unit. | |
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MedLine Citation:
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PMID: 22341537 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neonatal sepsis causes significant morbidity and mortality, especially in preterm infants. Clinicians are compelled to treat with empiric antibiotics at the first signs of suspected sepsis. Broad-spectrum antibiotics and prolonged treatment with empiric antibiotics are associated with adverse outcomes. Most common neonatal pathogens are susceptible to narrow-spectrum antibiotics. The choice of antibiotic and duration of empiric treatment are strongly associated with center-based risk factors. Clinicians should treat with short courses of narrow-spectrum antibiotics whenever possible, choosing the antibiotics and treatment duration to balance the risks of potentially untreated sepsis against the adverse effects of treatment in infants with sterile cultures. |
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Authors:
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Nidhi Tripathi; C Michael Cotten; P Brian Smith |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2011-12-29 |
Journal Detail:
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Title: Clinics in perinatology Volume: 39 ISSN: 1557-9840 ISO Abbreviation: Clin Perinatol Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-02-20 Completed Date: 2012-06-19 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 7501306 Medline TA: Clin Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 61-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Duke University Medical Center, Durham, NC 27710, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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adverse effects,
therapeutic use* Drug Administration Schedule Drug Resistance, Bacterial Humans Infant, Low Birth Weight Infant, Newborn Infant, Newborn, Diseases / drug therapy* Infant, Premature Infant, Premature, Diseases / drug therapy Intensive Care Units, Neonatal Microbial Sensitivity Tests Risk Factors Sepsis / drug therapy*, microbiology |
| Grant Support | |
ID/Acronym/Agency:
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1K23HD060040-01/HD/NICHD NIH HHS; 1R18AE000028-01/AE/ASPE HHS; K23 HD060040-04/HD/NICHD NIH HHS; L40 HD069892-04/HD/NICHD NIH HHS; TL1RR024126/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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