Document Detail


Antibiotic therapy for treatment of Chlamydia to prevent coronary heart disease events.
MedLine Citation:
PMID:  11122763     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Evidence is mounting that infectious agents might be involved in atherosclerosis. Therefore, antibiotic therapy might be helpful in its prevention. Early pilot therapeutic trials have targeted Chlamydia pneumoniae because it has the most evidence associating it with atherosclerosis. Small, randomized pilot trials that test the effect of macrolide therapy on future clinical events in patients with coronary artery disease have already shown promising but mixed results. Large clinical trials are presently underway that should provide more definitive information regarding the use of antibiotics in coronary artery disease. Until the results of these studies are available, it is not recommended that antibiotic therapy be routinely utilized for the treatment or prevention of complications of atherosclerosis.
Authors:
J B Muhlestein
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current atherosclerosis reports     Volume:  2     ISSN:  1523-3804     ISO Abbreviation:  Curr Atheroscler Rep     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2001-01-26     Completed Date:  2001-07-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100897685     Medline TA:  Curr Atheroscler Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  336-41     Citation Subset:  IM    
Affiliation:
Division of Cardiology, University of Utah, LDS Hospital, 8th Avenue & C Street, Salt Lake City, UT, 84143, USA. ldbmuhle@ihc.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Bacterial Agents / therapeutic use*
Arteriosclerosis / microbiology
Chlamydophila Infections / complications*,  drug therapy
Chlamydophila pneumoniae* / physiology
Coronary Disease / microbiology,  prevention & control*
Humans
Macrolides
Male
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Macrolides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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