| Antibiotic therapy for preterm premature rupture of membranes. | |
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MedLine Citation:
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PMID: 9646977 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Antibiotic treatment of the patient with preterm premature rupture of membranes remote from term significantly prolongs pregnancy and reduces amnionitis without increasing the risk of cesarean delivery. Antibiotic treatment reduces perinatal infectious morbidity including neonatal sepsis, GBS sepsis, and pneumonia. Stratified analysis of the currently available prospective trials also demonstrates a significant reduction in gestational-dependent morbidity, specifically respiratory distress and intraventricular hemorrhage with treatment. This is supported by a reduction in composite infant morbidity and other gestational age-dependent morbidities in the NICHD-MFMU trial. Although the optimal treatment regimen has not been determined, limited duration broad spectrum antibiotic treatment is justified in the setting of conservative management of pPROM remote from term. The patient with pPROM and documented pulmonary maturity near term may benefit more from expeditious delivery than from expectant management with antibiotics. |
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Authors:
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B M Mercer |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinical obstetrics and gynecology Volume: 41 ISSN: 0009-9201 ISO Abbreviation: Clin Obstet Gynecol Publication Date: 1998 Jun |
Date Detail:
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Created Date: 1998-09-08 Completed Date: 1998-09-08 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0070014 Medline TA: Clin Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 461-8 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of Tennessee, Memphis 38103, USA. Bmercer@utmem1.utmem.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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administration & dosage,
therapeutic use* Evidence-Based Medicine Female Fetal Membranes, Premature Rupture / drug therapy* Gestational Age Humans Maternal Mortality Multicenter Studies as Topic Pregnancy Pregnancy Complications, Infectious / drug therapy Randomized Controlled Trials as Topic |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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