Document Detail

Antibiotic therapy for preterm premature rupture of membranes.
MedLine Citation:
PMID:  9646977     Owner:  NLM     Status:  MEDLINE    
Antibiotic treatment of the patient with preterm premature rupture of membranes remote from term significantly prolongs pregnancy and reduces amnionitis without increasing the risk of cesarean delivery. Antibiotic treatment reduces perinatal infectious morbidity including neonatal sepsis, GBS sepsis, and pneumonia. Stratified analysis of the currently available prospective trials also demonstrates a significant reduction in gestational-dependent morbidity, specifically respiratory distress and intraventricular hemorrhage with treatment. This is supported by a reduction in composite infant morbidity and other gestational age-dependent morbidities in the NICHD-MFMU trial. Although the optimal treatment regimen has not been determined, limited duration broad spectrum antibiotic treatment is justified in the setting of conservative management of pPROM remote from term. The patient with pPROM and documented pulmonary maturity near term may benefit more from expeditious delivery than from expectant management with antibiotics.
B M Mercer
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical obstetrics and gynecology     Volume:  41     ISSN:  0009-9201     ISO Abbreviation:  Clin Obstet Gynecol     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-09-08     Completed Date:  1998-09-08     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0070014     Medline TA:  Clin Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  461-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Tennessee, Memphis 38103, USA.
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MeSH Terms
Anti-Bacterial Agents / administration & dosage,  therapeutic use*
Evidence-Based Medicine
Fetal Membranes, Premature Rupture / drug therapy*
Gestational Age
Maternal Mortality
Multicenter Studies as Topic
Pregnancy Complications, Infectious / drug therapy
Randomized Controlled Trials as Topic
Reg. No./Substance:
0/Anti-Bacterial Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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