Document Detail

Antibiotic therapy for preterm premature rupture of membranes - results of a multicenter study.
MedLine Citation:
PMID:  16602839     Owner:  NLM     Status:  MEDLINE    
AIMS: To evaluate whether primary application of mezlozillin in preterm premature rupture of membranes (pPROM) prolongs pregnancy and lowers neonatal morbidity. METHODS: In this prospective, randomized, double blind, placebo-controlled multicenter study a total of 105 pregnant women with pPROM between 24 + 0 and 32 + 6 weeks of gestation were examined receiving i.v. injections of corticoids and tocolytics as well as mezlocillin (3 x 2 g/d) or placebo. Assessed factors were prolongation of pregnancy and neonatal morbidity such as neonatal infection, respiratory distress syndrome (RDS), intraventricular hemorrhage (IVH) and necrotizing enterocolitis (NEC). RESULTS: Prolongation of pregnancy by more than 7 days was achieved in 63.8% of the mezlocillin group versus 44.8% of the placebo group (P < 0.05). The babies of mothers treated with anibiotics had fewer neonatal infections, RDS, IVH and NEC. Total morbidity was significantly lowered in the verum group (P = 0.02). CONCLUSIONS: Antibiotic administration following preterm premature rupture of membranes is associated with a prolongation of pregnancy and a reduction of neonatal infectious morbidity.
Norbert August Fuhr; Christian Becker; Andreas van Baalen; Karl Bauer; Hartmut Hopp
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  34     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  2006  
Date Detail:
Created Date:  2006-04-10     Completed Date:  2006-10-24     Revised Date:  2007-03-27    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  203-6     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Campus Benjamin Franklin, Charite Berlin, Germany.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use*
Bacterial Infections / epidemiology,  prevention & control
Cerebral Hemorrhage / epidemiology
Double-Blind Method
Enterocolitis, Necrotizing / epidemiology
Fetal Membranes, Premature Rupture / drug therapy*
Infant, Newborn
Infant, Newborn, Diseases / epidemiology,  prevention & control
Mezlocillin / therapeutic use*
Pregnancy Outcome
Prospective Studies
Respiratory Distress Syndrome, Newborn / epidemiology
Reg. No./Substance:
0/Anti-Bacterial Agents; 51481-65-3/Mezlocillin
Comment In:
J Perinat Med. 2006;34(6):503; author reply 504   [PMID:  17140303 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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