| Antibiotic therapy for preterm premature rupture of membranes - results of a multicenter study. | |
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MedLine Citation:
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PMID: 16602839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To evaluate whether primary application of mezlozillin in preterm premature rupture of membranes (pPROM) prolongs pregnancy and lowers neonatal morbidity. METHODS: In this prospective, randomized, double blind, placebo-controlled multicenter study a total of 105 pregnant women with pPROM between 24 + 0 and 32 + 6 weeks of gestation were examined receiving i.v. injections of corticoids and tocolytics as well as mezlocillin (3 x 2 g/d) or placebo. Assessed factors were prolongation of pregnancy and neonatal morbidity such as neonatal infection, respiratory distress syndrome (RDS), intraventricular hemorrhage (IVH) and necrotizing enterocolitis (NEC). RESULTS: Prolongation of pregnancy by more than 7 days was achieved in 63.8% of the mezlocillin group versus 44.8% of the placebo group (P < 0.05). The babies of mothers treated with anibiotics had fewer neonatal infections, RDS, IVH and NEC. Total morbidity was significantly lowered in the verum group (P = 0.02). CONCLUSIONS: Antibiotic administration following preterm premature rupture of membranes is associated with a prolongation of pregnancy and a reduction of neonatal infectious morbidity. |
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Authors:
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Norbert August Fuhr; Christian Becker; Andreas van Baalen; Karl Bauer; Hartmut Hopp |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of perinatal medicine Volume: 34 ISSN: 0300-5577 ISO Abbreviation: J Perinat Med Publication Date: 2006 |
Date Detail:
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Created Date: 2006-04-10 Completed Date: 2006-10-24 Revised Date: 2007-03-27 |
Medline Journal Info:
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Nlm Unique ID: 0361031 Medline TA: J Perinat Med Country: Germany |
Other Details:
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Languages: eng Pagination: 203-6 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Campus Benjamin Franklin, Charite Berlin, Germany. norbertaugust.fuhr@charite.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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therapeutic use* Bacterial Infections / epidemiology, prevention & control Cerebral Hemorrhage / epidemiology Double-Blind Method Enterocolitis, Necrotizing / epidemiology Female Fetal Membranes, Premature Rupture / drug therapy* Humans Infant, Newborn Infant, Newborn, Diseases / epidemiology, prevention & control Mezlocillin / therapeutic use* Pregnancy Pregnancy Outcome Prospective Studies Respiratory Distress Syndrome, Newborn / epidemiology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 51481-65-3/Mezlocillin |
| Comments/Corrections | |
Comment In:
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J Perinat Med. 2006;34(6):503; author reply 504
[PMID:
17140303
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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