Document Detail


Antibiotic susceptibility pattern of rapidly growing mycobacteria.
MedLine Citation:
PMID:  20622384     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The rapidly growing mycobacteria (RGM) causing human infections primarily consist of the Mycobacterium fortuitum group, Mycobacterium abscessus and Mycobacterium chelonae. The antibiotic susceptibility testing is important to determine the appropriate therapy as the antibiotics used to treat RGM are different from those used for treating infections caused by slow growers of mycobacteria. AIM: To determine antibiotic susceptibility of RGM using Kirby Bauer method and following Clinical and Laboratory Standards Institute (CLSI) guidelines. SETTINGS AND DESIGN: Larsen and Toubro Microbiology Research Centre, Vision Research Foundation, Sankara Nethralaya, Chennai, Retrospective study. MATERIALS AND METHODS: The antibiotic susceptibility testing was performed following CLSI method for the drugs Amikacin, Azithromycin, Tobramycin, Ceftazidime, Cephotaxime, Cefuroxime, Cefaperazone, Ceftriaxone, Ciprofloxacin, Ofloxacin, Norfloxacin, Gatifloxacin and Moxifloxacin. RESULTS AND CONCLUSIONS: Out of the 148 RGM isolates 146 (98%) were susceptible to amikacin, 138 (91%) to gatifloxacin, 132 (87%) to moxifloxacin, 122 (76%) to ciprofloxacin and 116 (74%) to Norfloxacin. Majority of the RGM were resistant to Ceftazidime, Cephotaxime and Cefaperazone. All the M. abscessus isolates were resistant to tobramycin. The in vitro antibiotic susceptibility testing by disc diffusion method showed that majority of the RGM were sensitive to Amikacin followed by Gatifloxacin, Moxifloxacin and Ciprofloxacin.
Authors:
R Gayathri; K Lily Therese; P Deepa; S Mangai; H N Madhavan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of postgraduate medicine     Volume:  56     ISSN:  0022-3859     ISO Abbreviation:  J Postgrad Med     Publication Date:    2010 Apr-Jun
Date Detail:
Created Date:  2010-07-12     Completed Date:  2010-09-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985196R     Medline TA:  J Postgrad Med     Country:  India    
Other Details:
Languages:  eng     Pagination:  76-8     Citation Subset:  IM    
Affiliation:
Larsen and Toubro Microbiology Research Centre, Vision Research Foundation, 18, College Road, Chennai, 600 006, India.
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / pharmacology*
Drug Resistance, Bacterial
Humans
India
Microbial Sensitivity Tests / methods
Mycobacterium Infections, Atypical / microbiology*
Mycobacterium chelonae / drug effects*,  genetics,  isolation & purification
Mycobacterium fortuitum / drug effects*,  genetics,  isolation & purification
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Retrospective Studies
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents

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