Document Detail


Antibiotic susceptibility of coagulase-negative staphylococci: emergence of teicoplanin non-susceptible CoNS strains with inducible resistance to vancomycin.
MedLine Citation:
PMID:  21799199     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Coagulase-negative staphylococci (CoNS) have become increasingly recognized as important agents of nosocomial infection. One of the characteristics of CoNS is their resistance to multiple antimicrobial agents commonly used for the treatment of staphylococcal infections. We studied 745 CoNS strains isolated from a university teaching hospital in China between 2004 and 2009. All strains were tested for antibiotics resistance. The antibiotics were placed into three categories based on resistance level of the CoNS strains to these antibiotics: High resistance (resistance rate >70%), including penicillin G, oxacillin, and erythromycin; Medium resistance (resistance rate between 30-70%), including tetracycline, clindamycin, ciprofloxacin, TMP/SMX, and chloramphenicol; Low resistance (resistance rate <30%), which includes rifampicin, ceftizoxime, and gentamicin. We also found that strains non-susceptible to teicoplanin increased from 4.5% to 6.7% between 2008 and 2009. A one-step vancomycin agar selection experiment and the subsequent population analysis revealed potential vancomycin resistant subpopulations that have been selected from the teicoplanin-nonsusceptible strains. A vigilant surveillance of nosocomial isolates of CoNS is needed to determine the resistance to glycopeptides.
Authors:
Xiao Xue Ma; En Hua Wang; Yong Liu; En Jie Luo
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-28
Journal Detail:
Title:  Journal of medical microbiology     Volume:  -     ISSN:  1473-5644     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0224131     Medline TA:  J Med Microbiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
China Medical University.
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