Document Detail


Antibiotic resistant N. gonorrhoeae in Trinidad and Tobago.
MedLine Citation:
PMID:  11785665     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We tested the susceptibility patterns of 128 N. gonorrhoeae isolates to six antimicrobials; penicillin, tetracycline, spectinomycin, ceftriaxone, ciprofloxacin and azithromycin, and examined whether certain demographic or behavioral factors related to antibiotic use increased the likelihood of infection by a resistant strain. There was a low rate of resistance to penicillin; penicillinase-producing and chromosomal-mediated penicillin resistant gonorrhea were estimated to be 0.8%. A much higher proportion of isolates were resistant to tetracycline (up to 15%). All isolates were sensitive to spectinomycin, ciprofloxacin and ceftriaxone. However, less than 2% of isolates displayed intermediate resistance to both ciprofloxacin and ceftriaxone, and 9% exhibited intermediate resistance to spectinomycin. Patients who had obtained medication before attending the clinic and had taken all of the medication were more likely (p = 0.03) to be infected with a resistant strain of gonococcus. Also, patients who were asked by a clinic doctor to return for a test of cure during an earlier clinic visit, but who did not return were more likely to be infected with a resistant organism (p = 0.006) compared to those who returned at the doctor's request. These findings have important implications for antibiotic use and educational programs in Trinidad and Tobago.
Authors:
D Castor; P Prabhakar; C Furlonge; A Rao; A Brown; B Camara; H Weiss; P E Jolly
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cellular and molecular biology (Noisy-le-Grand, France)     Volume:  47     ISSN:  0145-5680     ISO Abbreviation:  Cell. Mol. Biol. (Noisy-le-grand)     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2002-01-10     Completed Date:  2002-07-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9216789     Medline TA:  Cell Mol Biol (Noisy-le-grand)     Country:  France    
Other Details:
Languages:  eng     Pagination:  987-95     Citation Subset:  IM    
Affiliation:
Department of Epidemiology and International Health, School of Public Health and Medical Statistics Section, University of Alabama at Birmingham, 35294-0022, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anti-Bacterial Agents / pharmacology*,  therapeutic use
Azithromycin / pharmacology
Ceftriaxone / pharmacology
Cephalosporins / pharmacology
Ciprofloxacin / pharmacology
Drug Resistance, Multiple, Bacterial
Gonorrhea / drug therapy*,  epidemiology,  microbiology
Health Behavior
Humans
Microbial Sensitivity Tests
Neisseria gonorrhoeae / drug effects*,  enzymology,  isolation & purification
Penicillin Resistance
Penicillinase / biosynthesis
Penicillins / pharmacology
Prevalence
Spectinomycin / pharmacology
Tetracycline / pharmacology
Tetracycline Resistance
Trinidad and Tobago / epidemiology
Grant Support
ID/Acronym/Agency:
T37-TW0007/TW/FIC NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Cephalosporins; 0/Penicillins; 1695-77-8/Spectinomycin; 60-54-8/Tetracycline; 73384-59-5/Ceftriaxone; 83905-01-5/Azithromycin; 85721-33-1/Ciprofloxacin; EC 3.5.2.-/Penicillinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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