Document Detail

Antibiotic prophylaxis with cefotaxime in endoscopic extraction of upper urinary tract stones: a randomized study. The Cefotaxime Cooperative Group.
MedLine Citation:
PMID:  2228847     Owner:  NLM     Status:  MEDLINE    
This French multicentre, placebo-controlled, double-blind study investigated the efficacy of a single dose of cefotaxime 1 g iv in the prophylaxis of patients undergoing endoscopic extraction of urinary tract stones. Postoperative fever occurred in 12 patients in the placebo group and in nine in the cefotaxime group (no significant difference). The incidence of postoperative bacteriuria, between the first and third postoperative day, was significantly higher in the placebo group (15/60, 25%) than in the cefotaxime group (5/60, 8.5%). This controlled study clearly demonstrates the efficacy of antibiotic prophylaxis in endourological procedures. Cefotaxime significantly reduced the incidence of early postoperative bacteriuria without causing any significant side effects.
R O Fourcade
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  The Journal of antimicrobial chemotherapy     Volume:  26 Suppl A     ISSN:  0305-7453     ISO Abbreviation:  J. Antimicrob. Chemother.     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1990-12-11     Completed Date:  1990-12-11     Revised Date:  2013-03-14    
Medline Journal Info:
Nlm Unique ID:  7513617     Medline TA:  J Antimicrob Chemother     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  77-83     Citation Subset:  IM    
Department of Urology, Centre Hôpitalier d'Auxerre, France.
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MeSH Terms
Bacteriuria / prevention & control
Cefotaxime / administration & dosage,  therapeutic use*
Double-Blind Method
Middle Aged
Postoperative Complications / prevention & control
Urinary Calculi / surgery*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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