Document Detail

Antibiotic prophylaxis for pacemaker implantation: a prospective randomized trial.
MedLine Citation:
PMID:  6207497     Owner:  NLM     Status:  MEDLINE    
Prophylactic antibiotics are frequently prescribed for patients undergoing permanent pacemaker implantation even though data confirming their effectiveness are limited. Five hundred patients requiring elective permanent pacemaker implantation or generator replacement were prospectively randomized either to receive or not receive prophylactic antibiotic treatment at the time of implantation. The implantation site was treated with 10% povidone-iodine solution and 0.5% alcoholic chlorhexidine preoperatively. The wound were inspected for evidence of infection at 3 days and 1, 3, 6 and 12 months postimplantation. Three patients (two receiving prophylactic antibiotics and one no antibiotics) developed pacemaker pocket infection; Staphylococcus aureus was the pathogenic organism in each case (P = 0.56). Eighteen patients developed clinical evidence of superficial wound inflammation requiring antibiotic treatment but not pacemaker removal. Six had received prophylactic antibiotics and 12 had not (P = 0.27). We conclude that pacemaker pocket infection is unusual with careful preoperative skin preparation and close postoperative follow-up. Under these circumstances prophylactic antibiotic treatment is of no practical value.
D R Ramsdale; R G Charles; D B Rowlands; S S Singh; P C Gautam; E B Faragher
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  7     ISSN:  0147-8389     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  1984 Sep 
Date Detail:
Created Date:  1984-11-21     Completed Date:  1984-11-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  844-9     Citation Subset:  IM    
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MeSH Terms
Anti-Bacterial Agents / therapeutic use*
Clinical Trials as Topic
Electrodes, Implanted / adverse effects
Follow-Up Studies
Middle Aged
Pacemaker, Artificial* / adverse effects
Prospective Studies
Random Allocation
Surgical Wound Infection / drug therapy,  etiology
Reg. No./Substance:
0/Anti-Bacterial Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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