| Antibiotic prophylaxis for pacemaker implantation: a prospective randomized trial. | |
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MedLine Citation:
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PMID: 6207497 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prophylactic antibiotics are frequently prescribed for patients undergoing permanent pacemaker implantation even though data confirming their effectiveness are limited. Five hundred patients requiring elective permanent pacemaker implantation or generator replacement were prospectively randomized either to receive or not receive prophylactic antibiotic treatment at the time of implantation. The implantation site was treated with 10% povidone-iodine solution and 0.5% alcoholic chlorhexidine preoperatively. The wound were inspected for evidence of infection at 3 days and 1, 3, 6 and 12 months postimplantation. Three patients (two receiving prophylactic antibiotics and one no antibiotics) developed pacemaker pocket infection; Staphylococcus aureus was the pathogenic organism in each case (P = 0.56). Eighteen patients developed clinical evidence of superficial wound inflammation requiring antibiotic treatment but not pacemaker removal. Six had received prophylactic antibiotics and 12 had not (P = 0.27). We conclude that pacemaker pocket infection is unusual with careful preoperative skin preparation and close postoperative follow-up. Under these circumstances prophylactic antibiotic treatment is of no practical value. |
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Authors:
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D R Ramsdale; R G Charles; D B Rowlands; S S Singh; P C Gautam; E B Faragher |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Pacing and clinical electrophysiology : PACE Volume: 7 ISSN: 0147-8389 ISO Abbreviation: Pacing Clin Electrophysiol Publication Date: 1984 Sep |
Date Detail:
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Created Date: 1984-11-21 Completed Date: 1984-11-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7803944 Medline TA: Pacing Clin Electrophysiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 844-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Anti-Bacterial Agents / therapeutic use* Clinical Trials as Topic Electrodes, Implanted / adverse effects Female Follow-Up Studies Humans Male Middle Aged Pacemaker, Artificial* / adverse effects Premedication* Prospective Studies Random Allocation Surgical Wound Infection / drug therapy, etiology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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